1005095-06-6
1005095-06-6
Chemical Structure
SIRT2-IN-11
- CAS No.: 1005095-06-6
- Formula:C21H22N2O
- Molecular Weight:318.41
IUPAC Name: 6-phenyl-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide
InChIKey: XALTUCOIORLBHQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2NC(C3C(C4CCC3C4)C2=C1)C5=CC=CC=C5)N
Biological Activity: SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].
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SIRT2-IN-11 | 99.94% | SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers. | ||||||||||||||||||||
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References
Keywords
