Sirt1/2-IN-1
Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 2402779-21-7
- Formula: C22H13ClN2OS2
- Molecular Weight:420.93
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
SIRT1 1.81 μg/mL (IC50) |
SIRT2 2.10 μg/mL (IC50) |
SIRT3 20.5 μg/mL (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
2.34 μg/mL
Compound: 7
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
|
[PMID: 31812033] |
| UO-31 | IC50 |
12.41 μg/mL
Compound: 7
|
Cytotoxicity against human UO31 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human UO31 cells assessed as reduction in cell viability after 24 hrs by MTT assay
|
[PMID: 31812033] |
Chemical Information
-
CAS No. 2402779-21-7
-
Molecular Weight 420.93
-
Formula C22H13ClN2OS2
-
SMILES
O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)