1. Cell Cycle/DNA Damage
    Epigenetics
    Cytoskeleton
  2. Sirtuin
    Microtubule/Tubulin
  3. Sirt1/2-IN-1

Sirt1/2-IN-1 

Cat. No.: HY-146013
Handling Instructions

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.

For research use only. We do not sell to patients.

Sirt1/2-IN-1 Chemical Structure

Sirt1/2-IN-1 Chemical Structure

CAS No. : 2402779-21-7

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Description

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].

IC50 & Target

SIRT1

1.81 μg/mL (IC50)

SIRT2

2.10 μg/mL (IC50)

SIRT3

20.5 μg/mL (IC50)

Molecular Weight

420.93

Formula

C22H13ClN2OS2

CAS No.
SMILES

O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Sirt1/2-IN-1
Cat. No.:
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