2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. Sirtuin Microtubule/Tubulin
  4. Sirt1/2-IN-1

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.

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Sirt1/2-IN-1

Sirt1/2-IN-1 Chemical Structure

CAS No. : 2402779-21-7

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Sirt1/2-IN-1 Related Antibodies

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

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Description

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].

IC50 & Target

SIRT1

1.81 μg/mL (IC50)

SIRT2

2.10 μg/mL (IC50)

SIRT3

20.5 μg/mL (IC50)

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
2.34 μg/mL
Compound: 7
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 31812033]
UO-31 IC50
12.41 μg/mL
Compound: 7
Cytotoxicity against human UO31 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human UO31 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 31812033]
Masse moléculaire

420.93

Formule

C22H13ClN2OS2
CAS No.
SMILES

O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Sirt1/2-IN-1 Related Classifications

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Mass   Concentration   Volume   Molecular Weight *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sirt1/2-IN-12402779-21-7SirtuinMicrotubule/TubulinMCF-7UO-31anticancerα-tubulin protein acetylationInhibitorinhibitorinhibit

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