Sirt2-IN-6
Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC50 of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2243151-81-5
- Formula: C26H26N6O3S
- Molecular Weight:502.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SIRT2 0.815 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H441 | IC50 |
3.93 μM
Compound: 24a
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Antiproliferative activity against human NCI-H441 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H441 cells after 72 hrs by MTT assay
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[PMID: 29957526] |
Chemical Information
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CAS No. 2243151-81-5
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Molecular Weight 502.59
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Formula C26H26N6O3S
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SMILES
O=C(C1=CN(C)N=C1)NC2=CC=C(C=C2)OCC3=CC(NC(CSC4=NC(C)=CC(C)=N4)=O)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sirt2-IN-6 Related Classifications
HY-145958 Related Classifications
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