2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. FLS-359

FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC50 of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication.

For research use only. We do not sell to patients.

FLS-359

FLS-359 Chemical Structure

CAS No. : 2309398-79-4

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FLS-359 Related Antibodies

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Description

FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC50 of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication[1].

IC50 & Target

SIRT2

3 μM (IC50)

In Vitro

FLS-359 (0-100 μM) inhibits deacetylation of SIRT2 on a histone H3 site, with a substrate selectivity[1].
FLS-359 inhibits growth of multiple RNA and DNA virus, like SARS-CoV-2, Influenza A, Hepatitis B, respiratory syncytial virus, with IC50 range of 0.3-6.7 μM[1].
FLS-359 (0-10 μM, 24 h) inhibits the lytic activation of Epstein-Barr virus (EBV) in cells Akata, and the spread of human cytomegalovirus (HCMV) in diploid fibroblast with IC50 of 0.466 μM[1].
FLS-359 (0-5 μM, 72 h) inhibits the accumulation of intracellular viral nucleic acids, the production of extracellular virus particles, and the infectivity of the virus particles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FLS-359 Related Antibodies
In Vivo

FLS-359 (50 mg/kg, p.o., single dose) exhibits a good plasma exposure with a plasma half-life of 6 h, maximal plasma concentrations Cmax of 89 μM and an AUC of 713 μM•h/mL[1].
FLS-359 (50 mg/kg, p.o., twice daily for 11 days) inhibits HCMV infection in immunodeficient mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse gelfoam-fibroblast model and Human lung-only mouse model[1]
Dosage: 50 mg/kg
Administration: p.o., two time a day for 11 days
Result: Inhibited infection of HCMV.
Molecular Weight

466.60

Formula

C27H26N6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CN(C(C)=N1)C2=CC=C3CCN(CC3=C2)C4=NC=C(S4)CC5=CC=C(C=C5)N6C=CC=N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (214.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1432 mL 10.7158 mL 21.4316 mL
5 mM 0.4286 mL 2.1432 mL 4.2863 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1432 mL 10.7158 mL 21.4316 mL 53.5791 mL
5 mM 0.4286 mL 2.1432 mL 4.2863 mL 10.7158 mL
10 mM 0.2143 mL 1.0716 mL 2.1432 mL 5.3579 mL
15 mM 0.1429 mL 0.7144 mL 1.4288 mL 3.5719 mL
20 mM 0.1072 mL 0.5358 mL 1.0716 mL 2.6790 mL
25 mM 0.0857 mL 0.4286 mL 0.8573 mL 2.1432 mL
30 mM 0.0714 mL 0.3572 mL 0.7144 mL 1.7860 mL
40 mM 0.0536 mL 0.2679 mL 0.5358 mL 1.3395 mL
50 mM 0.0429 mL 0.2143 mL 0.4286 mL 1.0716 mL
60 mM 0.0357 mL 0.1786 mL 0.3572 mL 0.8930 mL
80 mM 0.0268 mL 0.1339 mL 0.2679 mL 0.6697 mL
100 mM 0.0214 mL 0.1072 mL 0.2143 mL 0.5358 mL
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FLS-359 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLS-3592309398-79-4FLS359FLS 359SirtuinMRC-5AkataHCMVEBVSARS-CoV-2Influenza AHepatitis BRSVrespiratory syncytial virusBALB/c mouse,CIEA NOG miceInhibitorinhibitorinhibit

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