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Cat. No.: HY-150119

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2'/3'-O-Acetyl-ADP-ribose sodium

2'/3'-O-Acetyl-ADP-ribose sodium is an inhibitor of cell division and oocyte maturation. 2'/3'-O-Acetyl-ADP-ribose sodium causes delay or arrest of oocyte maturation and blastomere division in embryos. 2'/3'-O-Acetyl-ADP-ribose sodium is produced by Sir2 family deacetylases during the coupling of histone/protein deacetylation with β-NAD+ cleavage. In neutral or weakly alkaline aqueous solutions, the direct enzymatic product forms of 2'/3'-O-Acetyl-ADP-ribose sodium, namely the 2'-O-acetyl form and the 3'-O-acetyl form, undergo intramolecular lactone exchange reaction and interconvert with each other.

For research use only. We do not sell to patients.

CAS No.: 1312013-29-8
Formula: C₁₇H₂₃N₅Na₂O₁₅P₂
Molecular Weight:645.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

2'/3'-O-Acetyl-ADP-ribose sodium Chemical Structure

CAS No.: 1312013-29-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

IC₅₀ & Target^[1]

SIRT2

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Chemical Information

CAS No. 1312013-29-8
Molecular Weight 645.32
Formula C₁₇H₂₃N₅Na₂O₁₅P₂
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OC[C@@H](O)[C@@H](O)[C@H](C=O)OC(C)=O)(O[Na])=O)(O[Na])=O)O3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jackson MD, et al. Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases. J Biol Chem. 2002;277(21):18535-18544. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2'/3'-O-Acetyl-ADP-ribose sodium

All Sirtuin Isoforms