1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

Thiomyristoyl 

Cat. No.: HY-101278 Purity: 98.84%
Data Sheet SDS Handling Instructions

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.

For research use only. We do not sell to patients.
Thiomyristoyl Chemical Structure

Thiomyristoyl Chemical Structure

CAS No. : 1429749-41-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $282 In-stock
1 mg $95 In-stock
5 mg $220 In-stock
10 mg $390 In-stock
25 mg $810 In-stock
50 mg $1400 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.

IC50 & Target

IC50: 28 nM (SIRT2)[1]

In Vitro

Thiomyristoyl (TM) is a potent SIRT2-specific inhibitor with broad anticancer activity but little effect on non-cancerous cells. SIRT2-inhibition promotes c-Myc ubiquitination and degradation, suggesting the therapeutic potential of TM to target certain c-Myc-driven cancers. TM could inhibit SIRT2 with an IC50 of 28 nM, but inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. TM inhibits three human breast cancer cell lines, MCF-7, MDA-MB-468, and MDA-MB-231[1].

In Vivo

TM inhibits tumor growth in mouse models of breast cancer. TM does not cause significant toxicity in mice and no significant weight loss is observed in TM-treated mice. S5H, the acetyl-a-tubulin level is moderately but statistically significantly increased in tumors from TM-treated mice compared with those from vehicle-treated mice, suggesting that TM indeed inhibits SIRT2 in vivo[1].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7187 mL 8.5933 mL 17.1866 mL
5 mM 0.3437 mL 1.7187 mL 3.4373 mL
10 mM 0.1719 mL 0.8593 mL 1.7187 mL
Cell Assay
[1]

Cells are seeded into 96-well plates at 3,000–4,000 cells per well. After 24 hr, test compounds (Thiomyristoyl) are added to cells to final concentrations ranging from 1 to 50 μM. Cells are then incubated for 72 hr and cell viability is measured using the CellTiter-Blue viability assay. Relative cell viability in the presence of test compounds is normalized to the vehicle-treated controls after background subtraction. GraphPad Prism software is used to determine the IC50 values. Knockdown of SIRT1-7 in various cell lines is achieved by lentiviral infection[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

581.85

Formula

C₃₄H₅₁N₃O₃S

CAS No.

1429749-41-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Thiomyristoyl
Cat. No.:
HY-101278
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