1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. Thiomyristoyl

Thiomyristoyl 

Cat. No.: HY-101278 Purity: 98.94%
Handling Instructions

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.

For research use only. We do not sell to patients.

Thiomyristoyl Chemical Structure

Thiomyristoyl Chemical Structure

CAS No. : 1429749-41-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 141 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 490 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Thiomyristoyl

    Thiomyristoyl purchased from MCE. Usage Cited in: Neoplasia. 2019 Mar 29;21(5):429-441. 

    HuCCT1 and RBE cells are treated with 0, 25, or 50 μm Tm (Thiomyristoyl) and subjected to western blotting

    Thiomyristoyl purchased from MCE. Usage Cited in: Neoplasia. 2019 Mar 29;21(5):429-441. 

    After treatment with Tm (Thiomyristoyl), NAC, or a combination of both, the levels of ROS and proteins are detected.

    Thiomyristoyl purchased from MCE. Usage Cited in: Neoplasia. 2019 Mar 29;21(5):429-441. 

    cMYC, p-PDHA1, PHGDH, PSAT1 and PSPH protein levels in xenograft tissues from control and Tm (Thiomyristoyl) group are detected by staining and Western blotting.

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    Description

    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.

    IC50 & Target[1]

    SIRT2

    28 nM (IC50)

    SIRT1

    98 μM (IC50)

    In Vitro

    Thiomyristoyl (TM) is a potent SIRT2-specific inhibitor with broad anticancer activity but little effect on non-cancerous cells. SIRT2-inhibition promotes c-Myc ubiquitination and degradation, suggesting the therapeutic potential of TM to target certain c-Myc-driven cancers. TM could inhibit SIRT2 with an IC50 of 28 nM, but inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. TM inhibits three human breast cancer cell lines, MCF-7, MDA-MB-468, and MDA-MB-231[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    TM inhibits tumor growth in mouse models of breast cancer. TM does not cause significant toxicity in mice and no significant weight loss is observed in TM-treated mice. S5H, the acetyl-a-tubulin level is moderately but statistically significantly increased in tumors from TM-treated mice compared with those from vehicle-treated mice, suggesting that TM indeed inhibits SIRT2 in vivo[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    581.85

    Formula

    C₃₄H₅₁N₃O₃S

    CAS No.

    1429749-41-6

    SMILES

    O=C(OCC1=CC=CC=C1)N[[email protected]](C(NC2=CC=CC=C2)=O)CCCCNC(CCCCCCCCCCCCC)=S

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (55.00 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7187 mL 8.5933 mL 17.1866 mL
    5 mM 0.3437 mL 1.7187 mL 3.4373 mL
    10 mM 0.1719 mL 0.8593 mL 1.7187 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.30 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.30 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Cell Assay
    [1]

    Cells are seeded into 96-well plates at 3,000–4,000 cells per well. After 24 hr, test compounds (Thiomyristoyl) are added to cells to final concentrations ranging from 1 to 50 μM. Cells are then incubated for 72 hr and cell viability is measured using the CellTiter-Blue viability assay. Relative cell viability in the presence of test compounds is normalized to the vehicle-treated controls after background subtraction. GraphPad Prism software is used to determine the IC50 values. Knockdown of SIRT1-7 in various cell lines is achieved by lentiviral infection[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Keywords:

    ThiomyristoylSirtuinInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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