1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. Sirtuin
    Apoptosis
  3. SIRT7 inhibitor 97491

SIRT7 inhibitor 97491 

Cat. No.: HY-135899 Purity: 98.05%
Handling Instructions

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..

For research use only. We do not sell to patients.

SIRT7 inhibitor 97491 Chemical Structure

SIRT7 inhibitor 97491 Chemical Structure

CAS No. : 1807758-81-1

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100 mg USD 2900 In-stock
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Description

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

IC50 & Target[1]

SIRT7

325 nM (IC50)

In Vitro

SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Human uterine sarcoma MES-SA cells
Concentration: 1, 5, 10 μM
Incubation Time: 72 hours
Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM.

Cell Cytotoxicity Assay[1]

Cell Line: Human embryonic kidney cell line HEK293 cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 hours
Result: HEK293 cells were almost unaffected.
In Vivo

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]
Dosage: 2 mg/kg
Administration: Intraperitoneally injected; for 3 weeks, except on weekends.
Result: Inhibited cancer growth in vivo.
Molecular Weight

285.73

Formula

C₁₅H₁₂ClN₃O

CAS No.

1807758-81-1

SMILES

NC1=CC(NC2=NC=C(C3=CC=C(Cl)C=C3)O2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 500 mg/mL (1749.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4998 mL 17.4990 mL 34.9981 mL
5 mM 0.7000 mL 3.4998 mL 6.9996 mL
10 mM 0.3500 mL 1.7499 mL 3.4998 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 4.17 mg/mL (14.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SIRT7 inhibitor 97491SirtuinApoptosisSIRT7deacetylasetumorp53 K373/382Inhibitorinhibitorinhibit

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Product Name:
SIRT7 inhibitor 97491
Cat. No.:
HY-135899
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