SIRT7 inhibitor 97491
Based on 6 publication(s) in Google Scholar
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..
For research use only. We do not sell to patients.
- Purity: 98.81%
- CAS No.: 1807758-81-1
- Formula: C15H12ClN3O
- Molecular Weight:285.73
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Antioxidant Compound Library
HY-L037
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Reprogramming Compound Library
HY-L039
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Oxygen Sensing Compound Library
HY-L045
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Glutamine Metabolism Compound Library
HY-L064
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Targeted Diversity Library
HY-L099
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Radioprotector Library
HY-L178
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Epigenetics Compound Library Mini
HY-L005M
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MCE Bioactive Compound Library
HY-L001V
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) SIRT7 inhibitor 97491
More
Biological Activity
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SIRT7 325 nM (IC50) |
SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human uterine sarcoma MES-SA cells
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Concentration:1, 5, 10 μM
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Incubation Time:72 hours
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Result:Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM.
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Cell Line:Human embryonic kidney cell line HEK293 cells
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Concentration:1, 5, 10 μM
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Incubation Time:24 hours
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Result:HEK293 cells were almost unaffected.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]
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Dosage:2 mg/kg
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Administration:Intraperitoneally injected; for 3 weeks, except on weekends.
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Result:Inhibited cancer growth in vivo.
Chemical Information
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CAS No. 1807758-81-1
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Appearance Solid
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Molecular Weight 285.73
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Formula C15H12ClN3O
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Color Off-white to light yellow
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SMILES
NC1=CC(NC2=NC=C(C3=CC=C(Cl)C=C3)O2)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (6)
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Journal Impact Factor
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Most Recent
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J Adv Res
Sirtuin 7-mediated deacetylation of hypoxia-inducible factor 1-alpha facilitates glycolytic reprogramming and inflammation of keratinocytes in psoriasis. [Abstract]2026 Apr 14:S2090-1232(26)00343-7. PMID: 41985670 -
Adv Sci (Weinh)
Fn14 Controls the SIRT2-Mediated Deacetylation of Slug to Inhibit the Metastasis of Epithelial Ovarian Cancer. [Abstract]2025 Jul;12(27):e2501552. PMID: 40344622 -
Antioxidants (Basel)
A Multi-Target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular Models. [Abstract]2024 Aug 22;13(8):1023. PMID: 39199267 -
Free Radic Biol Med
Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells. [Abstract]2024 Oct:223:30-41. PMID: 39053861 -
J Cell Biol
2023 May 1;222(5):e202201068. PMID: 37043189 -
Solvent & Solubility
DMSO : 500 mg/mL (1749.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (35.00 mM); Suspended solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4998 mL | 17.4990 mL | 34.9981 mL | 87.4952 mL |
| 5 mM | 0.7000 mL | 3.4998 mL | 6.9996 mL | 17.4990 mL | |
| 10 mM | 0.3500 mL | 1.7499 mL | 3.4998 mL | 8.7495 mL | |
| 15 mM | 0.2333 mL | 1.1666 mL | 2.3332 mL | 5.8330 mL | |
| 20 mM | 0.1750 mL | 0.8750 mL | 1.7499 mL | 4.3748 mL | |
| 25 mM | 0.1400 mL | 0.7000 mL | 1.3999 mL | 3.4998 mL | |
| 30 mM | 0.1167 mL | 0.5833 mL | 1.1666 mL | 2.9165 mL | |
| 40 mM | 0.0875 mL | 0.4375 mL | 0.8750 mL | 2.1874 mL | |
| 50 mM | 0.0700 mL | 0.3500 mL | 0.7000 mL | 1.7499 mL | |
| 60 mM | 0.0583 mL | 0.2917 mL | 0.5833 mL | 1.4583 mL | |
| 80 mM | 0.0437 mL | 0.2187 mL | 0.4375 mL | 1.0937 mL | |
| 100 mM | 0.0350 mL | 0.1750 mL | 0.3500 mL | 0.8750 mL |
SIRT7 inhibitor 97491 Related Classifications
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