1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. SirReal2

SirReal2 

Cat. No.: HY-100591 Purity: >99.0%
Handling Instructions

SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1.

For research use only. We do not sell to patients.

SirReal2 Chemical Structure

SirReal2 Chemical Structure

CAS No. : 709002-46-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 347 In-stock
Estimated Time of Arrival: December 31
5 mg USD 375 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

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Description

SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1[1].

IC50 & Target[1]

SIRT2

140 nM (IC50)

Molecular Weight

420.55

Formula

C₂₂H₂₀N₄OS₂

CAS No.

709002-46-0

SMILES

O=C(NC1=NC=C(CC2=C3C=CC=CC3=CC=C2)S1)CSC4=NC(C)=CC(C)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

SirReal2SirReal 2SirReal-2SirtuinInhibitorinhibitorinhibit

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SirReal2
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