Nicotinamide hydrochloride
Based on 97 publication(s) in Google Scholar
Nicotinamide hydrochloride is a form of vitamin B3 or niacin. Nicotinamide hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide hydrochloride also inhibits SIRT1. Nicotinamide hydrochloride increases cellular NAD+, ATP, ROS levels. Nicotinamide hydrochloride inhibits tumor growth and improves survival. Nicotinamide hydrochloride also has anti-HBV activity.
For research use only. We do not sell to patients.
- CAS No.: 25334-23-0
- Formula: C6H7ClN2O
- Molecular Weight:158.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Nicotinamide hydrochloride
More- Cancer Cell. 2024 Oct 14;42(10):1729-1746.e8. [Abstract]
- Nat Photonics. 2025 Jul 10.
- Nat Genet. 2023 Dec;55(12):2175-2188. [Abstract]
- Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9. [Abstract]
- Autophagy. 2020 Oct;16(10):1823-1837. [Abstract]
- Nat Commun. 2025 Mar 5;16(1):2200. [Abstract]
- Nat Commun. 2023 Sep 22;14(1):5917. [Abstract]
- Nat Commun. 2021 Sep 20;12(1):5548. [Abstract]
- Nat Commun. 2021 Jul 9;12(1):4227. [Abstract]
- Circ Res. 2022 Aug 19;131(5):456-472. [Abstract]
- J Adv Res. 2025 Jul 12:S2090-1232(25)00545-4. [Abstract]
- Cell Discov. 2024 Sep 17;10(1):96. [Abstract]
- Redox Biol. 2025 Aug 19:86:103834. [Abstract]
- Mol Cell. 2025 Apr 3;85(7):1349-1365.e10. [Abstract]
- Theranostics. 2019 Apr 13;9(9):2424-2438. [Abstract]
- Genes Dis. 2026 May 27.
- Acta Pharm Sin B. 2025 Dec;15(12):6382-6398. [Abstract]
- Acta Pharm Sin B. 2025 Nov;15(11):5803-5816. [Abstract]
- J Exp Clin Cancer Res. 2025 Feb 24;44(1):67. [Abstract]
- J Exp Clin Cancer Res. 2023 Jan 5;42(1):5. [Abstract]
- Cell Rep Med. 2025 Feb 18;6(2):101966. [Abstract]
- Cell Death Differ. 2023 Nov;30(11):2382-2392. [Abstract]
- Pharmacol Res. 2024 Dec 31:107573. [Abstract]
- Cell Death Dis. 2021 Sep 23;12(10):865. [Abstract]
- Cancer Lett. 2024 Jun 14:597:217005. [Abstract]
- Phytomedicine. 2025 Oct 15:148:157384. [Abstract]
- EBioMedicine. 2026 Apr 27:127:106256. [Abstract]
- Cell Death Discov. 2022 May 17;8(1):265. [Abstract]
- NPJ Precis Oncol. 2025 May 16;9(1):143. [Abstract]
- Oncogene. 2024 Oct;43(43):3170-3183. [Abstract]
- Oncogene. 2020 Mar;39(11):2437-2449. [Abstract]
- Apoptosis. 2025 Apr;30(3-4):768-783. [Abstract]
- Int J Biol Macromol. 2026 May:362:152113. [Abstract]
- Int J Biol Macromol. 2025 Jan 7:139619. [Abstract]
- Int J Biol Macromol. 2024 Jul 27:134120. [Abstract]
- EMBO J. 2020 Sep 15;39(18):e104365. [Abstract]
- Free Radic Biol Med. 2026 Jun 19:254:243-252. [Abstract]
- Cell Rep. 2026 May 28;45(6):117450. [Abstract]
- Cell Rep. 2026 Apr 25;45(5):117297. [Abstract]
- Aging Cell. 2021 Oct 3;e13491. [Abstract]
- Cell Prolif. 2024 Apr 16:e13646. [Abstract]
- J Ginseng Res. 2022 Nov;46(6):759-770. [Abstract]
- Hum Reprod. 2020 Mar 27;35(3):494-503. [Abstract]
- Hum Reprod. 2019 Jul 8;34(7):1186-1194. [Abstract]
- Ecotoxicol Environ Saf. 2024 Jul 18:282:116733. [Abstract]
- Cell Mol Life Sci. 2025 Oct 24;82(1):361. [Abstract]
- Cell Mol Life Sci. 2025 Apr 7;82(1):140. [Abstract]
- Cell Mol Life Sci. 2025 Apr 6;82(1):139. [Abstract]
- Oncoimmunology. 2025 Dec;14(1):2460281. [Abstract]
- EMBO Rep. 2025 Aug;26(16):4100-4123. [Abstract]
- Commun Biol. 2025 Jul 4;8(1):995. [Abstract]
- Commun Biol. 2023 Mar 2;6(1):235. [Abstract]
- Int Immunopharmacol. 2023 Jul:120:110279. [Abstract]
- Int J Mol Sci. 2022 Aug 12;23(16):9049. [Abstract]
- Invest Ophthalmol Vis Sci. 2026 Jan 5;67(1):21. [Abstract]
- Molecules. 2025 Oct 14;30(20):4082. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 May 13:167904. [Abstract]
- J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [Abstract]
- PLoS Pathog. 2026 Apr 22;22(4):e1014165. [Abstract]
- PLoS Pathog. 2024 Mar 12;20(3):e1012082. [Abstract]
- J Mol Cell Cardiol. 2022 Dec:173:154-168. [Abstract]
- Cell Signal. 2024 Sep 5:111386. [Abstract]
- iScience. 2026 Jan 27;29(2):114786. [Abstract]
- iScience. 2025 Sep 9;28(10):113520. [Abstract]
- iScience. 2025 Apr 3;28(5):112344. [Abstract]
- iScience. 2024 Aug 21;27(9):110775. [Abstract]
- Adv Photonics Res. 2026 Apr 18;7(4):e202500258.
- J Immunol. 2022 Aug 1;209(3):476-487. [Abstract]
- Am J Physiol Heart Circ Physiol. 2021 Aug 1;321(2):H353-H368. [Abstract]
- Toxicol Appl Pharmacol. 2026 Jun 23:514:117921. [Abstract]
- Br J Haematol. 2024 Dec;205(6):2432-2441. [Abstract]
- Exp Cell Res. 2022 Dec 15;421(2):113404. [Abstract]
- Cardiovasc Toxicol. 2022 Nov;22(10-11):898-909. [Abstract]
- Tissue Cell. 2025 Aug:95:102884. [Abstract]
- Chin J Integr Med. 2025 Feb;31(2):118-130. [Abstract]
- J Proteomics. 2024 May 24:105213. [Abstract]
- J Proteomics. 2023 May 30:280:104889. [Abstract]
- Am J Cancer Res. 2023 Feb 15;13(2):464-474. [Abstract]
- PeerJ. 2023 May 11:11:e15258. [Abstract]
- Theriogenology. 2020 Dec;158:233-238. [Abstract]
- Hum Cell. 2024 Nov 4;38(1):13. [Abstract]
- Chronobiol Int. 2025 Dec 11:1-11. [Abstract]
- STAR Protoc. 2026 Feb 19;7(1):104381. [Abstract]
- Hong Kong Polytechnic University. 2025.
- bioRxiv. 2025 Oct 14.
- bioRxiv. 2025 Aug 02.
- Res Sq. 2025 Jul 14.
- Patent. US20250129329A1.
- bioRxiv. 2025 April 30.
- bioRxiv. 2025 Apr 26:2025.04.23.650241. [Abstract]
- bioRxiv. 2025 March 24.
- SSRN. 2024 May 30.
- bioRxiv. 2023 Jun 6.
- Research Square Preprint. 2022 Feb.
- Oxid Med Cell Longev. 2021 Jan 19;2021:6610543. [Abstract]
- bioRxiv. 2020 Mar.
- Patent. US20180263995A1.
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
SIRT2 2 μM (EC50) |
SIRT1 50-180 μM (IC50) |
Nicotinamide hydrochloride (0-50 mM, 24/48 h ) reduces cell number in a time-dependent and dose-dependent manner in A375 and SK-MEL-28 cells[1].
Nicotinamide hydrochloride (10-50 mM, 24 h ) makes A375 cells undergo accumulation in G1 phase, reduction in S phase, and increase inthe sub-G1 (apoptosis) phase[1].
Nicotinamide hydrochloride (1-50 mM, 6 h ) increases NAD+, ATP and ROS levels in A375 and SK-MEL-28 cells[1].
Nicotinamide hydrochloride (0.01-20 mM, 1 h) inhibits purified SIRT2 enzymatic activity in vitro with an EC50 of 2 μM[1].
Nicotinamide hydrochloride (0-64 mM) inhibits HBV replication in HepAD38 and HepG2.2.15 cells[3].
Nicotinamide hydrochloride (10 mM, on day 13) promotes pancreatic cell differentiation from human embryonic stem cells (hESCs) through CK1 and ROCK inhibition[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375, SK-MEL-28, mouse B16-F10 cell
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Concentration:0, 1, 20, 50 mM
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Incubation Time:24 h, 48 h
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Result:Reduced cell number in a dose-dependent manner with a strong inhibitory effect at 20mM and an almost complete effect at 50 mM.
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Cell Line:A375, SK-MEL-28
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Concentration:10, 20, 50 mM
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Incubation Time:24 h
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Result:Arrested A375 cells in G1 phase.
Nicotinamide hydrochloride (Intraperitoneal injection, 1800 mg/Kg, once a day, murine metastatic melanoma model) affects IFN-γ (a key mediator of cell-mediated anti-tumor immunity), increases the plasma levels of Eotaxin and IL-5, reduces the plasma levels of IL-3, IL-12, RANTES and IL-10[1].
Nicotinamide hydrochloride (vein injection, 0-200 mg/kg, 5 days) inhibits HBV replication in HBV-transgenic mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (subcutaneous injected with B16-F10 cells)[1]
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Dosage:1000, 1500, 1800 mg/Kg.
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Administration:Intraperitoneal injection, 5 days per week (followed by 2-day rest) or once a day.
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Result:Inhibited tumor growth at 1500 and 1800 mg/Kg, and had no effect on the body weight. Increased the frequency of IFN-γ producing cells and modulated the protein levels of cytokines and chemokines in the plasma of tumor-bearing mice.
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Animal Model:HBV-transgenic mice[3]
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Dosage:0-200 mg/kg
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Administration:Vein injection, 5 days
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Result:Reduced serum HBV DNA.
Chemical Information
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CAS No. 25334-23-0
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Molecular Weight 158.59
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Formula C6H7ClN2O
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SMILES
O=C(C1=CC=CN=C1)N.[H]Cl
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Synonyms
Niacinamide hydrochloride; Nicotinic acid amide hydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (97)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer. [Abstract]2024 Oct 14;42(10):1729-1746.e8. PMID: 39303724 -
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Nat Genet
Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance. [Abstract]2023 Dec;55(12):2175-2188. PMID: 37985817 -
Cell Stem Cell
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal. [Abstract]2022 Sep 1;29(9):1366-1381.e9. PMID: 36055192 -
Autophagy
The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target. [Abstract]2020 Oct;16(10):1823-1837. PMID: 31986961 -
Nat Commun
2025 Mar 5;16(1):2200. PMID: 40038279 -
Nat Commun
SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity. [Abstract]2023 Sep 22;14(1):5917. PMID: 37739936 -
Nat Commun
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid. [Abstract]2021 Sep 20;12(1):5548. PMID: 34545082 -
Nat Commun
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. [Abstract]2021 Jul 9;12(1):4227. PMID: 34244482
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Jul 9;12(1):4227. [Abstract]
Nicotinamide (80 μM; 4-8 h) markedly increases GLDC K514 acetylation in U251 and U87 cells.
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Circ Res
2022 Aug 19;131(5):456-472. PMID: 35920168 -
J Adv Res
SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo. [Abstract]2025 Jul 12:S2090-1232(25)00545-4. PMID: 40659088 -
Cell Discov
Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer. [Abstract]2024 Sep 17;10(1):96. PMID: 39285160 -
Redox Biol
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer. [Abstract]2025 Aug 19:86:103834. PMID: 40850192 -
Mol Cell
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin. [Abstract]2025 Apr 3;85(7):1349-1365.e10. PMID: 40101711 -
Theranostics
EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter. [Abstract]2019 Apr 13;9(9):2424-2438. PMID: 31131045 -
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Acta Pharm Sin B
2025 Dec;15(12):6382-6398. PMID: 41477334 -
Acta Pharm Sin B
CRTAC1 derived from senescent FLSs induces chondrocyte mitochondrial dysfunction via modulating NRF2/SIRT3 axis in osteoarthritis progression. [Abstract]2025 Nov;15(11):5803-5816. PMID: 41311393 -
J Exp Clin Cancer Res
CD47 blockade reverses resistance to HDAC inhibitor by liberating anti-tumor capacity of macrophages. [Abstract]2025 Feb 24;44(1):67. PMID: 39994810 -
J Exp Clin Cancer Res
KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2. [Abstract]2023 Jan 5;42(1):5. PMID: 36600258 -
Cell Rep Med
KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC. [Abstract]2025 Feb 18;6(2):101966. PMID: 39970873 -
Cell Death Differ
Loss of SMURF2 expression enhances RACK1 stability and promotes ovarian cancer progression. [Abstract]2023 Nov;30(11):2382-2392. PMID: 37828084
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2023 Nov;30(11):2382-2392. [Abstract]
Nicotinamide (NAM) (10 mM, 4 h) enhances RACK1 acetylation levels in OVCAR3 and SKOV3 cells in combination with Trichostatin A (TSA) (HY-15144) (0.2 μM, 4 h).
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Pharmacol Res
YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice. [Abstract]2024 Dec 31:107573. PMID: 39746498
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Dec 31:107573. [Abstract]
Nicotinamide (NAM) enhanced ISO (10 μM)-induced YAP acetylation in neonatal rat cardiomyocytes (NRCMs).
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Cell Death Dis
Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway. [Abstract]2021 Sep 23;12(10):865. PMID: 34556628 -
Cancer Lett
Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression. [Abstract]2024 Jun 14:597:217005. PMID: 38880224 -
Phytomedicine
Diosgenin exerts dual impacts on Th17 cell differentiation in adjuvant-induced arthritis rats by impairing SIRT1-mediated deacetylation. [Abstract]2025 Oct 15:148:157384. PMID: 41101071 -
EBioMedicine
Integrated spatial multi-omics delineates fatty acid degradation fuels malignant evolution at the tumour periphery in cervical squamous cell carcinoma. [Abstract]2026 Apr 27:127:106256. PMID: 42048995 -
Cell Death Discov
Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis. [Abstract]2022 May 17;8(1):265. PMID: 35581193
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 May 17;8(1):265. [Abstract]
Nicotinamide (NAM) (6-8 h) upregulates stathmin1 acetylation in 293T cells transfected with stathmin1-Flag plasmids.
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NPJ Precis Oncol
Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2-mediated deacetylation modification to enhance aerobic glycolysis. [Abstract]2025 May 16;9(1):143. PMID: 40379975 -
Oncogene
USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2. [Abstract]2024 Oct;43(43):3170-3183. PMID: 39256572 -
Oncogene
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis. [Abstract]2020 Mar;39(11):2437-2449. PMID: 31974474 -
Apoptosis
Brazilin alleviates acute lung injury via inhibition of ferroptosis through the SIRT3/GPX4 pathway. [Abstract]2025 Apr;30(3-4):768-783. PMID: 39720978
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Apoptosis. 2025 Apr;30(3-4):768-783. [Abstract]
Nicotinamide (NAM) (20 mM; pretreatment for 24 hours before LPS exposure in MLE-12 cells) increases GPX4 acetylation levels in MLE-12 cells.
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Int J Biol Macromol
Acetylation of GPRC5A at Lys348 facilitates cisplatin resistance and promotes the recurrence and poor prognosis in ovarian cancer. [Abstract]2026 May:362:152113. PMID: 42009151 -
Int J Biol Macromol
SIRT5 desuccinylating IDH2 to alleviate oxidative stress in bovine mammary epithelial cells induced by ammonia. [Abstract]2025 Jan 7:139619. PMID: 39788270 -
Int J Biol Macromol
Inhibition of SIRT1 relieves hepatocarcinogenesis via alleviating autophagy and inflammation. [Abstract]2024 Jul 27:134120. PMID: 39074701 -
EMBO J
2020 Sep 15;39(18):e104365. PMID: 32696520 -
Free Radic Biol Med
SIRT5 desuccinylates ME2 to suppress oxidative stress in bovine mammary epithelial cells. [Abstract]2026 Jun 19:254:243-252. PMID: 42320846 -
Cell Rep
Targeting EP2/EP4-driven expansion of suppressive VSIG4high macrophages overcomes immunotherapy resistance in colorectal cancer. [Abstract]2026 May 28;45(6):117450. PMID: 42213779 -
Cell Rep
SEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization. [Abstract]2026 Apr 25;45(5):117297. PMID: 42035418 -
Aging Cell
Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation. [Abstract]2021 Oct 3;e13491. PMID: 34605151 -
Cell Prolif
Deletion of Tgm2 suppresses BMP-mediated hepatocyte-to-cholangiocyte metaplasia in ductular reaction. [Abstract]2024 Apr 16:e13646. PMID: 38623945 -
J Ginseng Res
Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons. [Abstract]2022 Nov;46(6):759-770. PMID: 36312736 -
Hum Reprod
Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility. [Abstract]2020 Mar 27;35(3):494-503. PMID: 32142584
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Hum Reprod. 2020 Mar 27;35(3):494-503. [Abstract]
Nicotinamide (NAM) (40 mM; 1 h) increases the global level of lysine 2-hydroxyisobutyrylation along the human sperm tail.
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Hum Reprod
2019 Jul 8;34(7):1186-1194. PMID: 31194865
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Hum Reprod. 2019 Jul 8;34(7):1186-1194. [Abstract]
Nicotinamide (NAM) (20-40 mM; 1 h) increases global levels of Kac (lysine acetylation) and Kglu (lysine glutarylation) in human sperm.
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Ecotoxicol Environ Saf
Nicotinamide improves the impaired extravillous trophoblast cell invasion induced by PM2.5 exposure-associated increase of TNFα secretion through the ROS/NF-κB/FLT1 pathway. [Abstract]2024 Jul 18:282:116733. PMID: 39029224 -
Cell Mol Life Sci
β-Hydroxybutyrate enhances malate dehydrogenase 2 β-hydroxybutyrylation to alleviate hepatic steatosis in MASLD. [Abstract]2025 Oct 24;82(1):361. PMID: 41134319 -
Cell Mol Life Sci
Loss of NgBR causes neuronal damage through decreasing KAT7-mediated RFX1 acetylation and FGF1 expression. [Abstract]2025 Apr 7;82(1):140. PMID: 40192836 -
Cell Mol Life Sci
Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells. [Abstract]2025 Apr 6;82(1):139. PMID: 40188417 -
Oncoimmunology
Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells. [Abstract]2025 Dec;14(1):2460281. PMID: 39902867
Nicotinamide hydrochloride purchased from MedChemExpress. Usage Cited in: Oncoimmunology. 2025 Dec;14(1):2460281. [Abstract]
Nicotinamide (NAM) (6 h) promotes CPT2 acetylation in SK-N-AS cells.
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EMBO Rep
PCAF-mediated acetylation regulates RAD51 dynamic localization on chromatin during HR repair. [Abstract]2025 Aug;26(16):4100-4123. PMID: 40664718 -
Commun Biol
Endometrial stromal Menin supports endometrial receptivity by maintaining homeostasis of WNT signaling pathway through H3K4me3 during WOI. [Abstract]2025 Jul 4;8(1):995. PMID: 40610728 -
Commun Biol
Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid. [Abstract]2023 Mar 2;6(1):235. PMID: 36864222 -
Int Immunopharmacol
Echinacoside ameliorates 5-fluorouracil-induced endothelial injury and senescence through SIRT1 activation. [Abstract]2023 Jul:120:110279. PMID: 37187128 -
Int J Mol Sci
Aberrant Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem Cells of a Retinitis Pigmentosa Patient with the PRPF6 Mutation. [Abstract]2022 Aug 12;23(16):9049. PMID: 36012314 -
Invest Ophthalmol Vis Sci
PRPF8 Mutation-Induced Defects in Human iPSC-Derived RPE Are Rescued by Adenine Base Editing. [Abstract]2026 Jan 5;67(1):21. PMID: 41533919 -
Molecules
Anti-Aging, Anti-Inflammatory, and Cytoprotective Properties of Lactobacillus- and Kombucha-Fermented C. pepo L. Peel and Pulp Extracts with Prototype Skin Toner Development. [Abstract]2025 Oct 14;30(20):4082. PMID: 41157100 -
Biochim Biophys Acta Mol Basis Dis
METTL3 promotes human amniotic epithelial stem cells differentiation into insulin-producing cells by regulation of MaFA expression. [Abstract]2025 May 13:167904. PMID: 40374016 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
PLoS Pathog
Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles. [Abstract]2026 Apr 22;22(4):e1014165. PMID: 42018568 -
PLoS Pathog
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation. [Abstract]2024 Mar 12;20(3):e1012082. PMID: 38470932 -
J Mol Cell Cardiol
Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair. [Abstract]2022 Dec:173:154-168. PMID: 36367517 -
Cell Signal
HDAC5 deacetylates c-Myc and facilitates cell cycle progression in hepatocellular carcinoma cells. [Abstract]2024 Sep 5:111386. PMID: 39243916 -
iScience
Biomimetic hydrogel for the construction of patient-derived bladder cancer organoids with aggressive growth. [Abstract]2026 Jan 27;29(2):114786. PMID: 41704753 -
iScience
ALKBH5-IGF2BP2 axis mediates prostate cancer progression and docetaxel resistance via m6A-stabilized CLSPN RNA. [Abstract]2025 Sep 9;28(10):113520. PMID: 41069850 -
iScience
2025 Apr 3;28(5):112344. PMID: 40276762 -
iScience
Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial-mesenchymal transition and invasion. [Abstract]2024 Aug 21;27(9):110775. PMID: 39286495 -
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J Immunol
Deacetylation of K481 and K484 on Penaeid Shrimp Hemocyanin Is Critical for Antibacterial Activity. [Abstract]2022 Aug 1;209(3):476-487. PMID: 35851542 -
Am J Physiol Heart Circ Physiol
Soluble epoxide hydrolase deletion attenuated nicotine-induced arterial stiffness via limiting the loss of SIRT1. [Abstract]2021 Aug 1;321(2):H353-H368. PMID: 34142887 -
Toxicol Appl Pharmacol
Salidroside suppresses hypoxia-induced ocular angiogenesis by modulating the acetylation of PFKFB3 protein in endothelial cells and regulating glycolytic activity. [Abstract]2026 Jun 23:514:117921. PMID: 42336299 -
Br J Haematol
Nicotinamide enhances Treg differentiation by promoting Foxp3 acetylation in immune thrombocytopenia. [Abstract]2024 Dec;205(6):2432-2441. PMID: 39406393 -
Exp Cell Res
Inhibition of 14-3-3ε by K50 acetylation activates YAP1 to promote cholangiocarcinoma growth. [Abstract]2022 Dec 15;421(2):113404. PMID: 36341908 -
Cardiovasc Toxicol
Genistein Alleviates Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus by Activating the Sirt1/Nrf2 Pathway in High Salt-Induced Hypertension. [Abstract]2022 Nov;22(10-11):898-909. PMID: 35986807 -
Tissue Cell
Melatonin promotes diabetic wound healing by mediating mitochondrial function in endothelial cells through the AMPK/SIRT1/HIF-1α pathway. [Abstract]2025 Aug:95:102884. PMID: 40233668 -
Chin J Integr Med
Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway. [Abstract]2025 Feb;31(2):118-130. PMID: 39671057 -
J Proteomics
Global proteomic analyses of lysine acetylation, malonylation, succinylation, and crotonylation in human sperm reveal their involvement in male fertility. [Abstract]2024 May 24:105213. PMID: 38797435 -
J Proteomics
Global proteomic analysis reveals lysine succinylation contributes to the pathogenesis of aortic aneurysm and dissection. [Abstract]2023 May 30:280:104889. PMID: 36966968 -
Am J Cancer Res
SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy. [Abstract]2023 Feb 15;13(2):464-474. PMID: 36895980 -
PeerJ
Tandem mass tag-based quantitative proteomic analysis identification of succinylation related proteins in pathogenesis of thoracic aortic aneurysm and aortic dissection. [Abstract]2023 May 11:11:e15258. PMID: 37193023 -
Theriogenology
Diet-induced obesity is associated with altered expression of sperm motility-related genes and testicular post-translational modifications in a mouse model. [Abstract]2020 Dec;158:233-238. PMID: 32980686 -
Hum Cell
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Purity & Documentation
References
[1]. Francesca Scatozza, et al. Nicotinamide inhibits melanoma in vitro and in vivo. J Exp Clin Cancer Res. 2020 Oct 7;39(1):211. [Content Brief]
[2]. Hwang ES, et al. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell Mol Life Sci. 2017 Sep;74(18):3347-3362. [Content Brief]
[3]. Li WY, et al. The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. Arch Virol. 2016 Mar;161(3):621-30. [Content Brief]
[4]. Zhang Y, et al. Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells. Stem Cell Res Ther. 2021 Jun 25;12(1):362. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nicotinamide hydrochloride Related Classifications
HY-B0150A Related Classifications
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