SIRT2-IN-18
SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3 and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 858032-59-4
- Formula: C21H12N2O3
- Molecular Weight:340.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hSIRT2 12.3 μM (IC50) |
Schistosoma mansoniSIRT2 5.3 μM (IC50) |
Chemical Information
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CAS No. 858032-59-4
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Molecular Weight 340.33
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Formula C21H12N2O3
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SMILES
O=C(C1=CC2=C(OC1=NC3=O)C=CC4=C2C=CC=C4)N3C5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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