SIRT2-IN-18
SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3 and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis.
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- CAS No.: 858032-59-4
- Formule: C21H12N2O3
- Masse moléculaire:340.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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hSIRT2 12.3 μM (IC50) |
Schistosoma mansoniSIRT2 5.3 μM (IC50) |
Chemical Information
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CAS No. 858032-59-4
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Masse moléculaire 340.33
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Formule C21H12N2O3
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SMILES
O=C(C1=CC2=C(OC1=NC3=O)C=CC4=C2C=CC=C4)N3C5=CC=CC=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIRT2-IN-18 Related Classifications
HY-178773 Related Classifications
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