SIRT6-IN-4
SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC50 of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC50 of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models.
For research use only. We do not sell to patients.
- CAS No.: 3075160-74-3
- Formula: C26H18ClN5O
- Molecular Weight:451.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SIRT6 5.86 μM (IC50) |
SIRT2 157.2 μM (IC50) |
SIRT3 274.1 μM (IC50) |
SIRT1 311.9 μM (IC50) |
Chemical Information
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CAS No. 3075160-74-3
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Molecular Weight 451.91
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Formula C26H18ClN5O
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SMILES
O=C(C1=CC2=C(N(C3=C2C=C(C=C3)Cl)CC4=CC=C(C=C4)C#N)C=N1)NCC5=CC=CC=N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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