3075160-74-3
3075160-74-3
Chemical Structure
SIRT6-IN-4
- CAS No.: 3075160-74-3
- Formula:C26H18ClN5O
- Molecular Weight:451.91
InChIKey: BDHRUEDKFUTDIH-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(N(C3=C2C=C(C=C3)Cl)CC4=CC=C(C=C4)C#N)C=N1)NCC5=CC=CC=N5
Biological Activity: SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC50 of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC50 of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models[1].
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SIRT6-IN-4 | SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC50 of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC50 of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models. | |||||||||||||||||||||
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References
Keywords
