Sirtuin-IN-1
Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma.
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- CAS 番号: 1392810-44-4
- 分子式: C24H28N4O4
- 分子量:436.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
|
SIRT1 6.2 μM (IC50) |
SIRT2 4.2 μM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hs 683 | IC50 |
4 μM
Compound: 18
|
Antiproliferative activity against human Hs683 cells after 72 hrs by MTT assay
Antiproliferative activity against human Hs683 cells after 72 hrs by MTT assay
|
[PMID: 28475330] |
| T98G | IC50 |
14 μM
Compound: 18
|
Antiproliferative activity against human T98G cells after 72 hrs by MTT assay
Antiproliferative activity against human T98G cells after 72 hrs by MTT assay
|
[PMID: 28475330] |
| U-373MG ATCC | IC50 |
6 μM
Compound: 18
|
Antiproliferative activity against human U373 cells after 72 hrs by MTT assay
Antiproliferative activity against human U373 cells after 72 hrs by MTT assay
|
[PMID: 28475330] |
化学情報
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CAS 番号 1392810-44-4
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分子量 436.51
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分子式 C24H28N4O4
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SMILES
N#CC1=CC=CC(=C1)NC(=O)NC2C3=CC(=CC=C3OC(C)(C)C2)NC(=O)OC(C)(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Schnekenburger M, et al. Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2017 Jun 8;60(11):4714-4733. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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