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Cat. No.: HY-153509

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Sirtuin-IN-1

Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC₅₀s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma.

For research use only. We do not sell to patients.

CAS No.: 1392810-44-4
Formula: C₂₄H₂₈N₄O₄
Molecular Weight:436.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Sirtuin-IN-1 Chemical Structure

CAS No.: 1392810-44-4

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

SIRT1

6.2 μM (IC₅₀)

SIRT2

4.2 μM (IC₅₀)

All Sirtuin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hs 683	IC₅₀	4 μM Compound: 18	Antiproliferative activity against human Hs683 cells after 72 hrs by MTT assay Antiproliferative activity against human Hs683 cells after 72 hrs by MTT assay	[PMID: 28475330]
T98G	IC₅₀	14 μM Compound: 18	Antiproliferative activity against human T98G cells after 72 hrs by MTT assay Antiproliferative activity against human T98G cells after 72 hrs by MTT assay	[PMID: 28475330]
U-373MG ATCC	IC₅₀	6 μM Compound: 18	Antiproliferative activity against human U373 cells after 72 hrs by MTT assay Antiproliferative activity against human U373 cells after 72 hrs by MTT assay	[PMID: 28475330]

Chemical Information

CAS No. 1392810-44-4
Molecular Weight 436.51
Formula C₂₄H₂₈N₄O₄
SMILES

N#CC1=CC=CC(=C1)NC(=O)NC2C3=CC(=CC=C3OC(C)(C)C2)NC(=O)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schnekenburger M, et al. Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2017 Jun 8;60(11):4714-4733. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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