1392810-44-4
1392810-44-4
Chemical Structure
Sirtuin-IN-1
- CAS No.: 1392810-44-4
- Formula:C24H28N4O4
- Molecular Weight:436.51
IUPAC Name: tert-butyl (4-(3-(3-cyanophenyl)ureido)-2,2-dimethylchroman-6-yl)carbamate
InChIKey: CJYMCBSCMOLHIE-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC(=C1)NC(=O)NC2C3=CC(=CC=C3OC(C)(C)C2)NC(=O)OC(C)(C)C
Biological Activity: Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma[1].
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Sirtuin-IN-1 | Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma. | |||||||||||||||||||||
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References
- [1]. Schnekenburger M, et al. Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2017 Jun 8;60(11):4714-4733. [Content Brief]
Keywords
