AC-93253
Based on 1 Customer Validation
AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors.
For research use only. We do not sell to patients.
- CAS No.: 108527-83-9
- Formula: C23H25IN2S
- Molecular Weight:488.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SIRT1 45.3 μM (IC50) |
SIRT2 6 μM (IC50) |
SIRT3 24.6 μM (IC50) |
In Vitro
AC93253 can inhibit SIRT1, SIRT2 and SIRT3 with IC50 values of 45.3 μM, 6 μM and 24.6 μM, respectively[1].
AC-93253 (0, 2, 5, 10 μM; 16 h) significantly enhanced the acetylation of tubulin, p53, and histone H4[1].
AC-93253 exhibits selective cytotoxicity towards four tumor cell lines in a single agent with IC50 values ranging from 10 to 100 nM[1].
AC-93253 significantly triggered apoptosis [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:NCI-H460 cells, HeLa cells
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Concentration:0, 2, 5, 10 μM
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Incubation Time:16 h
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Result:Increased the acetylation levels of a-tubulin in a dose-dependent manner.
Increased the level of histone protein and p53.
Chemical Information
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CAS No. 108527-83-9
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Appearance Solid
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Molecular Weight 488.43
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Formula C23H25IN2S
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Color Brown to dark brown
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SMILES
CC1(C)C2=C(C=CC=C2)N(C)/C1=C/C=C/C3=[N+](CC)C4=C(C=CC=C4)S3.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AC-93253 Related Classifications
HY-118343 Related Classifications
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