AC-93253
Based on 1 Customer Validation
AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors.
For research use only. We do not sell to patients.
- CAS No.: 108527-83-9
- Formula: C23H25IN2S
- Molecular Weight:488.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SIRT1 45.3 μM (IC50) |
SIRT2 6 μM (IC50) |
SIRT3 24.6 μM (IC50) |
AC93253 can inhibit SIRT1, SIRT2 and SIRT3 with IC50 values of 45.3 μM, 6 μM and 24.6 μM, respectively[1].
AC-93253 (0, 2, 5, 10 μM; 16 h) significantly enhanced the acetylation of tubulin, p53, and histone H4[1].
AC-93253 exhibits selective cytotoxicity towards four tumor cell lines in a single agent with IC50 values ranging from 10 to 100 nM[1].
AC-93253 significantly triggered apoptosis [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H460 cells, HeLa cells
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Concentration:0, 2, 5, 10 μM
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Incubation Time:16 h
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Result:Increased the acetylation levels of a-tubulin in a dose-dependent manner.
Increased the level of histone protein and p53.
Chemical Information
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CAS No. 108527-83-9
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Appearance Solid
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Molecular Weight 488.43
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Formula C23H25IN2S
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Color Brown to dark brown
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SMILES
CC1(C)C2=C(C=CC=C2)N(C)/C1=C/C=C/C3=[N+](CC)C4=C(C=CC=C4)S3.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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