1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. Dihydrocoumarin

Dihydrocoumarin (Synonyms: Hydrocoumarin; Chroman-2-one)

Cat. No.: HY-N1926 Purity: 99.18%
Handling Instructions

Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

For research use only. We do not sell to patients.

Dihydrocoumarin Chemical Structure

Dihydrocoumarin Chemical Structure

CAS No. : 119-84-6

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively[1].

IC50 & Target

hSIRT1

208 μM (IC50)

hSIRT2

295 μM (IC50)

In Vitro

Dihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC50 of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM)[1].
Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line[1].
Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

148.16

Formula

C₉H₈O₂

CAS No.
SMILES

O=C1CCC2=CC=CC=C2O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (674.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7495 mL 33.7473 mL 67.4946 mL
5 mM 1.3499 mL 6.7495 mL 13.4989 mL
10 mM 0.6749 mL 3.3747 mL 6.7495 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.81%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

DihydrocoumarinHydrocoumarin Chroman-2-oneSirtuinInhibitorinhibitorinhibit

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Product Name:
Dihydrocoumarin
Cat. No.:
HY-N1926
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