1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

SIRT-IN-1 

Cat. No.: HY-16615
Handling Instructions

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

For research use only. We do not sell to patients.

SIRT-IN-1 Chemical Structure

SIRT-IN-1 Chemical Structure

CAS No. : 1431411-60-7

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  • References

Description

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

IC50 & Target

SIRT1

15 nM (IC50)

SIRT2

10 nM (IC50)

SIRT3

33 nM (IC50)

In Vitro

SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5673 mL 12.8363 mL 25.6726 mL
5 mM 0.5135 mL 2.5673 mL 5.1345 mL
10 mM 0.2567 mL 1.2836 mL 2.5673 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

389.52

Formula

C₁₉H₂₇N₅O₂S

CAS No.

1431411-60-7

SMILES

NC(C1=CC2=NC=NC(N3CCC(CCNC(C(C)(C)C)=O)CC3)=C2S1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
SIRT-IN-1
Cat. No.:
HY-16615
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SIRT-IN-1

Cat. No.: HY-16615