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Cat. No.: HY-115979

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Sirt2-IN-5

Sirt2-IN-5 is a potent SIRT2 inhibtor.

For research use only. We do not sell to patients.

CAS No.: 902456-47-7
Formula: C₂₆H₂₇Cl₂N₅O₃
Molecular Weight:528.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Sirt2-IN-5 Chemical Structure

CAS No.: 902456-47-7

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Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Sirt2-IN-5 is a potent SIRT2 inhibtor^[1].

IC₅₀ & Target^[1]

SIRT2

All Sirtuin Isoforms :

In Vitro

Sirt2-IN-5 shows 47.95% SIRT2 inhibition at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 902456-47-7
Molecular Weight 528.43
Formula C₂₆H₂₇Cl₂N₅O₃
SMILES

O=C1C(C2=CC=C(Cl)C=C2)=CC(N3CCOCC3)=NN1CC(N4CCN(C5=CC=CC(Cl)=C5)CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sukuroglu, M.K., et al. The potential of 4-aryl-6-morpholino-3(2H)-pyridazinone-2-arylpiperazinylacetamide as a new scaffold for SIRT2 inhibition: in silico approach guided by pharmacophore mapping and molecular docking. Med Chem Res 30, 1915–1924 (2021).

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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