1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. Sirt2-IN-1

Sirt2-IN-1 

Cat. No.: HY-112427 Purity: 98.03%
Handling Instructions

Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM.

For research use only. We do not sell to patients.

Sirt2-IN-1 Chemical Structure

Sirt2-IN-1 Chemical Structure

CAS No. : 1862238-00-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 675 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM[1].

IC50 & Target[1]

SIRT2

163 nM (IC50)

Molecular Weight

557.69

Formula

C₂₈H₂₇N₇O₂S₂

CAS No.

1862238-00-3

SMILES

O=C(NC1=NC=C(CC2=CC=CC(OCC3=CN(CC4=CC=CC=C4)N=N3)=C2)S1)CSC5=NC(C)=CC(C)=N5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (268.97 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7931 mL 8.9656 mL 17.9311 mL
5 mM 0.3586 mL 1.7931 mL 3.5862 mL
10 mM 0.1793 mL 0.8966 mL 1.7931 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Sirt2-IN-1
Cat. No.:
HY-112427
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