1. Cell Cycle/DNA Damage Epigenetics
  2. Sirtuin
  3. SIRT1-IN-2

SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM.

For research use only. We do not sell to patients.

SIRT1-IN-2 Chemical Structure

SIRT1-IN-2 Chemical Structure

CAS No. : 2470969-89-0

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Based on 1 publication(s) in Google Scholar

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Description

SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM[1].

IC50 & Target

SIRT1

1.6 μM (IC50)

SIRT2

39 μM (IC50)

In Vitro

SIRT1-IN-2 (compound 3h) (0-100 μM, 48 h) inhibits the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, and shows significantly less cytotoxic on 293T cells and HUVEC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC). [1]
Concentration: 0, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 h
Result: Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, with IC50 values of 51, 37, 40, 48, and 48 μM, respectively. And showed significantly less cytotoxic on 293T cells and HUVEC, with IC50 values of > 100 and 45 μM, respectively.
Molecular Weight

250.72

Formula

C13H15ClN2O

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC(C1=C(NC2=CC=C(C=C21)Cl)CC(N)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (398.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9885 mL 19.9426 mL 39.8851 mL
5 mM 0.7977 mL 3.9885 mL 7.9770 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9885 mL 19.9426 mL 39.8851 mL 99.7128 mL
5 mM 0.7977 mL 3.9885 mL 7.9770 mL 19.9426 mL
10 mM 0.3989 mL 1.9943 mL 3.9885 mL 9.9713 mL
15 mM 0.2659 mL 1.3295 mL 2.6590 mL 6.6475 mL
20 mM 0.1994 mL 0.9971 mL 1.9943 mL 4.9856 mL
25 mM 0.1595 mL 0.7977 mL 1.5954 mL 3.9885 mL
30 mM 0.1330 mL 0.6648 mL 1.3295 mL 3.3238 mL
40 mM 0.0997 mL 0.4986 mL 0.9971 mL 2.4928 mL
50 mM 0.0798 mL 0.3989 mL 0.7977 mL 1.9943 mL
60 mM 0.0665 mL 0.3324 mL 0.6648 mL 1.6619 mL
80 mM 0.0499 mL 0.2493 mL 0.4986 mL 1.2464 mL
100 mM 0.0399 mL 0.1994 mL 0.3989 mL 0.9971 mL
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SIRT1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SIRT1-IN-2
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HY-146689
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