SIRT2 - sirtuin 2 Gene

Also Known as SIR2; SIR2L; SIR2L2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22933

About SIRT2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,878,555-38,899,618 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 187 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the Sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

SIRT2 Products (7)

mRNA	Protein	Name
NM_001193286.2	NP_001180215.1	NAD-dependent protein deacetylase sirtuin-2 isoform 3
XM_047438469.1	XP_047294425.1	NAD-dependent protein deacetylase sirtuin-2 isoform X3
NM_030593.3	NP_085096.1	NAD-dependent protein deacetylase sirtuin-2 isoform 2
XM_047438468.1	XP_047294424.1	NAD-dependent protein deacetylase sirtuin-2 isoform X1
NR_034146.1
XM_011526655.2	XP_011524957.1	NAD-dependent protein deacetylase sirtuin-2 isoform X2
NM_012237.4	NP_036369.2	NAD-dependent protein deacetylase sirtuin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12887892	GOA
enables NAD+ binding	IDA IDA: Inferred from direct assay	11427894	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	10381378	GOA
enables NAD-dependent histone H4K16 deacetylase activity	IDA IDA: Inferred from direct assay	16648462	GOA
NOT enables NAD-dependent histone deacetylase activity	IDA IDA: Inferred from direct assay	24177535	GOA
enables NAD-dependent histone deacetylase activity	IDA IDA: Inferred from direct assay	11427894	GOA
enables NAD-dependent protein demyristoylase activity	IDA IDA: Inferred from direct assay	25704306	GOA
enables NAD-dependent protein depalmitoylase activity	IDA IDA: Inferred from direct assay	32103017	GOA
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	18722353	GOA
enables NAD-dependent protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	24681946	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	23908241	GOA
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	12887892	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	17488717	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12620231	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12697818	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	17172643	GOA
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	23908241	GOA
NOT enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	24177535	GOA
enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	12620231	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	12697818	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	11427894	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	24681946	GOA
involved in epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23908241	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12887892	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	20543840	GOA
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	20543840	GOA
involved in negative regulation of striated muscle tissue development	IDA IDA: Inferred from direct assay	12887892	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18722353	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24681946	GOA
involved in peptidyl-lysine deacetylation	IDA IDA: Inferred from direct assay	23932781	GOA
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	23932781	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24681946	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21841822	GOA
NOT involved in protein deacetylation	IDA IDA: Inferred from direct assay	24177535	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	20543840	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	17726514	GOA
NOT involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	24177535	GOA
involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	18722353	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	17726514	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17488717	GOA
located in chromosome	IDA IDA: Inferred from direct assay	16648462	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12697818	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24681946	GOA
located in microtubule	IDA IDA: Inferred from direct assay	12620231	GOA
located in midbody	IDA IDA: Inferred from direct assay	17726514	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	17488717	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15213244	GOA
located in spindle	IDA IDA: Inferred from direct assay	17726514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT2 Protein Structure

SIR2

0
100
200
300
389 a.a.

Protein Preferred Names	Protein Names
NAD-dependent protein deacetylase sirtuin-2	NAD-dependent deacetylase sirtuin-2 NAD-dependent protein defatty-acylase sirtuin-2 SIR2-like protein 2 regulatory protein SIR2 homolog 2 silent information regulator 2 sir2-related protein type 2 sirtuin type 2

SIRT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SIRT2	Q8IXJ6	BUB1B	Homo sapiens	O60566	Anti Bait CoIP	24825348
Intra	SIRT2	Q8IXJ6	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
Intra	SIRT2	Q8IXJ6	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	SIRT2	Q8IXJ6	G6PD	Homo sapiens	P11413	Anti Tag CoIP	24769394
Intra	SIRT2	Q8IXJ6	KAT2B	Homo sapiens	Q92831	Anti Tag CoIP	12887892
Intra	SIRT2	Q8IXJ6	RELA	Homo sapiens	Q04206	Anti Bait CoIP	21081649

Cross: Cross-species interaction Intra: Intraspecies interaction

SIRT2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80320	SIRT2 Antibody (YA081)	WB, ICC/IF, IP, FC	Human, Rat
HY-P85521	SirT2 Antibody (YA5213)	WB, ICC/IF	Human, Mouse, Rat
HY-P85521A	SirT2 Antibody (YA5213)(PBS only)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Wallerian Degeneration	Wallerian Degeneration Of The Pyramidal Tract
Monckeberg Arteriosclerosis	Monckeberg Medial Calcific Sclerosis
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0150	Nicotinamide	Inhibitor	99.98%	Unkown
HY-B0879A	Suramin sodium salt	Inhibitor	99.98%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown
HY-B0150A	Nicotinamide hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B0150R	Nicotinamide (Standard)	Inhibitor	99.85%	Phase 4

Pre-clinical Phase

Bioactive Molecules (59)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10532	SRT 1720	Activator	99.90%	Unkown
HY-100578	AGK2	Inhibitor	99.43%	Unkown
HY-107454	OSS_128167	Inhibitor	98.92%	Unkown
HY-13515	Sirtinol	Inhibitor	98.0%	Unkown
HY-100591	SirReal2	Inhibitor	99.0%	Unkown
HY-16691	AK-7	Inhibitor	99.63%	Unkown
HY-100732	Cambinol	Inhibitor	99.89%	Unkown
HY-15510	Tenovin-6	Inhibitor	98.00%	Unkown
HY-101278	Thiomyristoyl	Inhibitor	98.23%	Unkown
HY-15145	SRT 1720 monohydrochloride	Activator	99.92%	Unkown
HY-101073	Salermide	Inhibitor	98.0%	Unkown
HY-16616	SIRT-IN-2	Inhibitor	98.08%	Unkown
HY-136199	SIRT1-IN-1	Inhibitor	98.15%	Unkown
HY-103721	SIRT6-IN-2	Inhibitor	99.92%	Unkown
HY-103636	PROTAC Sirt2 Degrader-1	Inhibitor	99.09%	Unkown
HY-16605	SIRT6-IN-6	Inhibitor	98.59%	Unkown
HY-N1926	Dihydrocoumarin	Inhibitor	99.81%	Unkown
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	Unkown
HY-101465	AK-1	Inhibitor	99.84%	Unkown
HY-112427	Sirt2-IN-1	Inhibitor	98.71%	Unkown
HY-111522	RK-9123016	Inhibitor	99.65%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-107660	SIRT2-IN-8	Inhibitor	98.45%	Unkown
HY-16615	SIRT-IN-1	Inhibitor	98.14%	Unkown
HY-123653	SirReal-1	Inhibitor	99.82%	Unkown
HY-146689	SIRT1-IN-2	Inhibitor	98.31%	Unkown
HY-111329	JGB1741	Inhibitor	99.37%	Unkown
HY-146690	SIRT1-IN-3	Inhibitor	99.12%	Unkown
HY-163532	FLS-359	Modulator	95.41%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	98.37%	Unkown
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	Unkown
HY-P3364A	Ac-QPKK(Ac)-AMC acetate	Substrate	99.38%	Unkown
HY-107453	SirReal1-O-propargyl	Ligand	/	Unkown
HY-147233	MIND4-19	Inhibitor	99.93%	Unkown
HY-148408	SIRT2-IN-11	Inhibitor	99.94%	Unkown
HY-118343	AC-93253	Inhibitor	99.3%	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-160617	SIRT2-IN-14	Inhibitor	/	Unkown
HY-160944	hsa62	Inhibitor	/	Unkown
HY-153509	Sirtuin-IN-1	Inhibitor	/	Unkown
HY-145958	Sirt2-IN-6	Inhibitor	/	Unkown
HY-149637	HSP70/SIRT2-IN-1	Inhibitor	/	Unkown
HY-185682	NCO-141	Inhibitor	/	Unkown
HY-W841840	SR94	Inhibitor	/	Unkown
HY-179388	PROTAC Sirt2 Degrader-2	Degrader	/	Unkown
HY-136713	Sirt1/2-IN-5	Inhibitor	/	Unkown
HY-150119	2'/3'-O-Acetyl-ADP-ribose sodium	Substrate	/	Unkown
HY-114510	PRMT/HKMT-IN-1		/	Unkown
HY-115979	Sirt2-IN-5	Inhibitor	/	Unkown
HY-114906	SIRT1/2/3-IN-2	Inhibitor	/	Unkown
HY-146013	Sirt1/2-IN-1	Inhibitor	/	Unkown
HY-W197205	SL010110	Inhibitor	/	Unkown
HY-183870	NCO-90	Inhibitor	/	Unkown
HY-182412	NH4-6	Inhibitor	/	Unkown
HY-170402	SIRT6-IN-4	Inhibitor	/	Unkown
HY-W109401	SIRT-IN-6	Inhibitor	/	Unkown
HY-119889	A1B11	Inhibitor	/	Unkown
HY-178773	SIRT2-IN-18	Inhibitor	/	Unkown
HY-117442	A2B57	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SIRT2	VGNC	VGNC:34631
Felis catus	SIRT2	VGNC	VGNC:65156
Canis familiaris	SIRT2	VGNC	VGNC:53983
Rattus norvegicus	SIRT2	RGD	RGD:621481
Macaca mulatta	SIRT2	VGNC	VGNC:77219
Mus musculus	SIRT2	MGD	MGI:1927664
Others	SIRT2	NCBI