Sirt1/2-IN-5 

Sirt1/2-IN-5 is a SIRT1/SIRT2 inhibitor with human SIRT1 IC₅₀ 0.3 μM and human SIRT2 IC₅₀ values 1.2 μM and pIC₅₀ 5.82. Sirt1/2-IN-5 inhibits NAD⁺-dependent deacetylase activity of SIRT1 and SIRT2. Sirt1/2-IN-5 can be used for the research of cancer, neurodegenerative disease^[1][2].

Sirt1/2-IN-5 (Compound 3) inhibits human recombinant SIRT1 with an IC₅₀ of 0.3 μM and human recombinant SIRT2 with an IC₅₀ of 1.2 μM^[1].
Sirt1/2-IN-5 (Compound 17) potently inhibits human Sirt2 enzymatic activity with a pIC₅₀ of 5.82, with binding predominantly driven by van der Waals forces^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

282.32

C₁₅H₁₀N₂O₂S

143034-06-4

O=C1NC(=S)NC(=O)C1=CC2=CC=CC=3C=CC=CC32

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• [1]. Blum CA, et al. SIRT1 modulation as a novel approach to the treatment of diseases of aging. J Med Chem. 2011 Jan 27;54(2):417-32.

  [2]. Uciechowska U, et al. Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+ dependent histone deacetylase Sirt2. \tMed. Chem. Commun. 2011 Nov 28;2:167-173.