Sirt1/2-IN-5
Sirt1/2-IN-5 is a SIRT1/SIRT2 inhibitor with human SIRT1 IC50 0.3 μM and human SIRT2 IC50 values 1.2 μM and pIC50 5.82. Sirt1/2-IN-5 inhibits NAD+-dependent deacetylase activity of SIRT1 and SIRT2. Sirt1/2-IN-5 can be used for the research of cancer, neurodegenerative disease.
For research use only. We do not sell to patients.
- CAS No.: 143034-06-4
- Formula: C15H10N2O2S
- Molecular Weight:282.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hSIRT1 0.3 μM (IC50) |
hSIRT2 1.2 μM (IC50) |
hSIRT2 5.82 (pIC50) |
Sirt1/2-IN-5 (Compound 3) inhibits human recombinant SIRT1 with an IC50 of 0.3 μM and human recombinant SIRT2 with an IC50 of 1.2 μM[1].
Sirt1/2-IN-5 (Compound 17) potently inhibits human Sirt2 enzymatic activity with a pIC50 of 5.82, with binding predominantly driven by van der Waals forces[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 143034-06-4
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Molecular Weight 282.32
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Formula C15H10N2O2S
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SMILES
O=C1NC(=S)NC(=O)C1=CC2=CC=CC=3C=CC=CC32
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sirt1/2-IN-5 Related Classifications
HY-136713 Related Classifications
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