143034-06-4
143034-06-4
Chemical Structure
Sirt1/2-IN-5
- CAS No.: 143034-06-4
- Formula:C15H10N2O2S
- Molecular Weight:282.32
IUPAC Name: 5-(naphthalen-1-ylmethylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
InChIKey: QPTGWITYTSXRJB-UHFFFAOYSA-N
SMILES: O=C1NC(=S)NC(=O)C1=CC2=CC=CC=3C=CC=CC32
Biological Activity: Sirt1/2-IN-5 is a SIRT1/SIRT2 inhibitor with human SIRT1 IC50 0.3 μM and human SIRT2 IC50 values 1.2 μM and pIC50 5.82. Sirt1/2-IN-5 inhibits NAD+-dependent deacetylase activity of SIRT1 and SIRT2. Sirt1/2-IN-5 can be used for the research of cancer, neurodegenerative disease[1][2].
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Sirt1/2-IN-5 | Sirt1/2-IN-5 is a SIRT1/SIRT2 inhibitor with human SIRT1 IC50 0.3 μM and human SIRT2 IC50 values 1.2 μM and pIC50 5.82. Sirt1/2-IN-5 inhibits NAD+-dependent deacetylase activity of SIRT1 and SIRT2. Sirt1/2-IN-5 can be used for the research of cancer, neurodegenerative disease. | |||||||||||||||||||||
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References
- [1]. Blum CA, et al. SIRT1 modulation as a novel approach to the treatment of diseases of aging. J Med Chem. 2011 Jan 27;54(2):417-32. [Content Brief]
- [2]. Uciechowska U, et al. Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+ dependent histone deacetylase Sirt2. \tMed. Chem. Commun. 2011 Nov 28;2:167-173.
Keywords
