1. Cell Cycle/DNA Damage
    Epigenetics
    PROTAC
  2. Sirtuin
    PROTAC

PROTAC Sirt2 Degrader-1 

Cat. No.: HY-103636
Handling Instructions

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM).

For research use only. We do not sell to patients.

PROTAC Sirt2 Degrader-1 Chemical Structure

PROTAC Sirt2 Degrader-1 Chemical Structure

CAS No. : 2098487-75-1

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  • Biological Activity

  • Technical Information

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  • References

Description

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].

IC50 & Target[1]

SIRT2

0.25 μM (IC50)

In Vitro

PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 µM
Incubation Time: 1-6 hours
Result: Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1724 mL 5.8621 mL 11.7242 mL
5 mM 0.2345 mL 1.1724 mL 2.3448 mL
10 mM 0.1172 mL 0.5862 mL 1.1724 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

852.94

Formula

C₄₀H₄₀N₁₀O₈S₂

CAS No.

2098487-75-1

SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN4C=C(COC5=CC(CC6=CN=C(NC(CSC7=NC(C)=CC(C)=N7)=O)S6)=CC=C5)N=N4)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PROTAC Sirt2 Degrader-1
Cat. No.:
HY-103636
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PROTAC Sirt2 Degrader-1

Cat. No.: HY-103636