2. Cell Cycle/DNA Damage
    Epigenetics
    PROTAC
  3. Sirtuin
    PROTACs
  4. PROTAC Sirt2 Degrader-1

PROTAC Sirt2 Degrader-1 

Cat. No.: HY-103636 Purity: 98.50%
COA Handling Instructions

PROTAC Sirt2 Degrader-1 est un PROTAC basé sur SirReal, agit comme un dégradeur de Sirt2, composé d'un inhibiteur de Sirt2 qui est très puissant et sélectif pour l'isotype. , un lieur et un ligand cérébrique de bonne foi pour l'ubiquitine ligase E3. PROTAC Sirt2 Degrader-1 affiche un IC50 de 0,25 μM pour Sirt2, sans effet sur Sirt1/Sirt3 (IC50s>100 μM ).

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).

For research use only. We do not sell to patients.

PROTAC Sirt2 Degrader-1 Chemical Structure

PROTAC Sirt2 Degrader-1 Chemical Structure

CAS No. : 2098487-75-1

Size Price Stock Quantity
5 mg USD 900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM)[1].

IC50 & Target[1]

SIRT2

0.25 μM (IC50)

In Vitro

PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 µM
Incubation Time: 1-6 hours
Result: Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
Molecular Weight

852.94

Appearance

Solid

Formula

C40H40N10O8S2
CAS No.
SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN4C=C(COC5=CC(CC6=CN=C(NC(CSC7=NC(C)=CC(C)=N7)=O)S6)=CC=C5)N=N4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (117.24 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1724 mL 5.8621 mL 11.7242 mL
5 mM 0.2345 mL 1.1724 mL 2.3448 mL
10 mM 0.1172 mL 0.5862 mL 1.1724 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.93 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC Sirt2 Degrader-12098487-75-1SirtuinPROTACsInhibitorinhibitorinhibit

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