1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. CHIC35

CHIC35 

Cat. No.: HY-111303
Handling Instructions

CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 µM) or SIRT3 (IC50>100 µM). CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research.

For research use only. We do not sell to patients.

CHIC35 Chemical Structure

CHIC35 Chemical Structure

CAS No. : 848193-72-6

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Description

CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 µM) or SIRT3 (IC50>100 µM)[1]. CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research[1][2].

IC50 & Target

SIRT1

0.124 μM (IC50)

SIRT2

2.8 μM (IC50)

SIRT3

>100 μM (IC50)

In Vitro

CHIC-35 (0.5 μM; 16 hours) increases acetylation of histone H4 in BMDMs similar to Cambinol (200 μM)[1].
CHIC-35 (5 μM; 72 hours) exhibits no significant difference in the survival of embryos at early stages[2].
Zebrafish embryos are microinjected with 2.4 ng of chd7 MO to develop to different stages of development. chd7 morphant embryos are treated with CHIC-35 from 8hpf to 24hpf. CHIC-35 (5 μM) is removed at 24hpf and embryos are incubated in fresh egg water until 4dpf. The chd7 morphant larvae has a severely reduced and disrupted pattern of cartilage elements in comparison to the control, CHIC-35 shows partial recovery in craniofacial cartilage elements[2].
At 4dpf, zebrafish embryos show a well-formed lower jaw in controls, while chd7 morphants exhibits reduced lower jaw. Treatment with CHIC-35 (5 μM) rescues the expression of sox9a inchd7 morphants[2].
Nearly 30% of chd7 morphant embryos (24hpf to 72hpf) shows a near complete loss of isl2a expression in the cranial region compared to 10% of the wildtype controls. CHIC-35 reduces this to 7.5% significantly. However, CHIC-35 shows no discernible effect on the enteric neurons marked by Tg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

262.73

Formula

C₁₄H₁₅ClN₂O

CAS No.
SMILES

O=C([[email protected]]1CCCCC2=C1NC3=C2C=C(Cl)C=C3)N

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CHIC35CHIC 35CHIC-35SirtuinInflammatoryinnate immune responseseptic shockcongenital disorderCHD7CHARGE syndromeInhibitorinhibitorinhibit

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