848193-72-6
848193-72-6
Chemical Structure
CHIC35
- CAS No.: 848193-72-6
- Formula:C14H15ClN2O
- Molecular Weight:262.73
IUPAC Name: (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide
InChIKey: ABIVOOWWGYJNLV-JTQLQIEISA-N
SMILES: O=C([C@H]1CCCCC2=C1NC3=C2C=C(Cl)C=C3)N
Biological Activity: CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM)[1]. CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research[1][2].
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CHIC35 | CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM). CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research. | |||||||||||||||||||||
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References
- [1]. Jérôme Lugrin, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510 [Content Brief]
- [2]. Zainab Asad, et al. Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorate disease-like phenotypes in embryo. Eur J Med Genet. 2020 Feb;63(2):103661. [Content Brief]
Keywords
