1. NF-κB
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  3. Gossypin

Gossypin 

Cat. No.: HY-125911 Purity: 98.04%
Handling Instructions

Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro.

For research use only. We do not sell to patients.

Gossypin Chemical Structure

Gossypin Chemical Structure

CAS No. : 652-78-8

Size Price Stock Quantity
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro[1][2].

IC50 & Target

IC50: NF-κB[1]

Molecular Weight

480.38

Formula

C21H20O13

CAS No.
SMILES

O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=C(O[[email protected]]4[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O4)O)O)O)C(O)=CC(O)=C13

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (520.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0817 mL 10.4084 mL 20.8169 mL
5 mM 0.4163 mL 2.0817 mL 4.1634 mL
10 mM 0.2082 mL 1.0408 mL 2.0817 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Gossypin
Cat. No.:
HY-125911
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