Art. -Nr.: HY-108353

Isoprenaline

94 Cited Publications

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Based on 94 publication(s) in Google Scholar

Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.

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Reinheit: 98.93%
CAS. Nr.: 7683-59-2
Formel: C₁₁H₁₇NO₃
Molecular Weight:211.26

Speicherung:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Isoprenaline Chemical Structure

CAS. Nr.: 7683-59-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (94)
Lösungsmittel & Löslichkeit
- In Vitro
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Biologische Aktivität

Beschreibung

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
C3H 10T1/2	EC₅₀	19 nM Compound: Isoproterenol	Induction of lipolysis in mouse C3H10T1/2 assessed as glycerol concentration Induction of lipolysis in mouse C3H10T1/2 assessed as glycerol concentration	[PMID: 21330134]
C6	EC₅₀	7 nM Compound: Isoproterenol	Beta adrenergic receptor agonistic activity for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cells Beta adrenergic receptor agonistic activity for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cells	[PMID: 1672155]
CHO	EC₅₀	0.084 nM Compound: Isoproterenol	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor	[PMID: 15603933]
CHO	EC₅₀	0.97 nM Compound: Isoproterenol	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-3 adrenergic receptor Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-3 adrenergic receptor	[PMID: 15603933]
CHO	EC₅₀	2 nM Compound: Isoproterenol	Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-2 adrenergic receptor Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-2 adrenergic receptor	[PMID: 15603933]
CHO	EC₅₀	3.9 nM Compound: isoproterenol	Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay	[PMID: 18083578]
CHO	EC₅₀	5.8 nM Compound: isoproterenol	Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method	[PMID: 18083578]
CHO	EC₅₀	0.084 nM Compound: ISP	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	0.97 nM Compound: ISP	Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	0.084 nM Compound: ISP	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	[PMID: 18553954]
CHO	EC₅₀	0.97 nM Compound: ISP	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	[PMID: 18553954]
CHO	EC₅₀	2 nM Compound: ISP	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	[PMID: 18553954]
CHO	EC₅₀	0.084 nM Compound: ISP	Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 18651730]
CHO	EC₅₀	0.97 nM Compound: ISP	Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 18651730]
CHO	EC₅₀	2 nM Compound: ISP	Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 18651730]
CHO	EC₅₀	0.084 nM Compound: ISP	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 18752946]
CHO	EC₅₀	0.97 nM Compound: ISP	Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 18752946]
CHO	EC₅₀	0.003 μM Compound: ISO	Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	[PMID: 19232786]
CHO	EC₅₀	0.012 μM Compound: ISO	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	[PMID: 19232786]
CHO	EC₅₀	0.1 μM Compound: ISO	Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay	[PMID: 19232786]
CHO	EC₅₀	0.003 μM Compound: ISO	Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 19362005]
CHO	EC₅₀	0.012 μM Compound: ISO	Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 19362005]
CHO	EC₅₀	0.1 μM Compound: ISO	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation	[PMID: 19362005]
CHO	EC₅₀	0.84 nM Compound: ISP	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	0.97 nM Compound: ISP	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	2 nM Compound: ISP	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	0.003 μM Compound: ISO	Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	[PMID: 19581100]
CHO	EC₅₀	0.012 μM Compound: ISO	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	[PMID: 19581100]
CHO	EC₅₀	0.1 μM Compound: ISO	Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay	[PMID: 19581100]
CHO	EC₅₀	1 μM Compound: ISO	Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	[PMID: 19581100]
CHO	EC₅₀	1 μM Compound: ISO	Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	[PMID: 19581100]
CHO	EC₅₀	1 μM Compound: ISO	Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol	[PMID: 19581100]
CHO	EC₅₀	0.84 nM Compound: ISP	Agonist activity at human recombinant adrenergic beta2 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay Agonist activity at human recombinant adrenergic beta2 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	[PMID: 19608416]
CHO	EC₅₀	2 nM Compound: ISP	Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay	[PMID: 19608416]
CHO	EC₅₀	86 nM Compound: isoproterenol	Agonist activity at human recombinant beta3-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins Agonist activity at human recombinant beta3-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins	[PMID: 26125514]
HEK293	EC₅₀	0.2 nM Compound: Isoproterenol	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	[PMID: 24326276]
HEK293	EC₅₀	120 nM Compound: Isoprenaline	Agonist activity at PK-tagged beta2 receptor (unknown origin) transfected in HEK293 cells after 90 mins by beta-arrestin assay Agonist activity at PK-tagged beta2 receptor (unknown origin) transfected in HEK293 cells after 90 mins by beta-arrestin assay	[PMID: 27132867]
HEK293	EC₅₀	87 nM Compound: Isoprenaline	Agonist activity at human beta2 receptor expressed in HEK293 cells cotransfected with Gqs5 protein assessed as [3H]IP3 accumulation after 120 mins by scintillation counting assay in presence of myo-[3H]-inositol Agonist activity at human beta2 receptor expressed in HEK293 cells cotransfected with Gqs5 protein assessed as [3H]IP3 accumulation after 120 mins by scintillation counting assay in presence of myo-[3H]-inositol	[PMID: 27132867]
Sf21	IC₅₀	>1000 μM Compound: Isoproterenol	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	>1000 μM Compound: Isoproterenol	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]

In Vitro

Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-K_m cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells^[1].
Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity^[2].
Isoprenaline (5 nM and 10 μM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO)^[3].
Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged^[4].
Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca²⁺ current^[5].
Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isoprenaline (oral, 0.27-0. 64 μg/kg) is extensively metabolizes by a relatively small number of reactions in dogs^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dogs^[1]
Dosage:

0.27-0. 64 μg/kg
Administration:

oral
Result:

Excreted largely unchanged in urine, only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.
Showed plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.
. Showed heart rate returned to base-line values when high plasma concentrations.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 7683-59-2
Appearance Solid
Molecular Weight 211.26
Formel C₁₁H₁₇NO₃
Color Light brown to brown
SMILES

OC1=CC=C(C(O)CNC(C)C)C=C1O
Structure Classification
- Alkaloids
- Other Alkaloids
- Phenols
- Polyphenols
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Publications (94)

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Nature

The astrocytic ensemble acts as a multiday trace to stabilize memory. [Abstract]

2025 Dec;648(8092):146-156. PMID: 41094146
Science

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia. [Abstract]

2020 Dec 4;370(6521):eaay2002. PMID: 33093214
Circulation

Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling. [Abstract]

2018 Jun 5;137(23):2497-2513. PMID: 29371215
Cancer Discov

Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression. [Abstract]

2026 Feb 9. PMID: 41661076
Cell Mol Immunol

β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response. [Abstract]

2023 Feb;20(2):175-188. PMID: 36600052

Isoprenaline purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]

Isoprenaline hydrochloride (ISO; 10 μM; 6 h), markedly inhibits SeV- or HSV-1-induced transcription of the IFNB1 and CXCL10 genes in THP1 cells.

Isoprenaline purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]

Isoprenaline hydrochloride (ISO; 10 μM; 0, 3, 6, 9 h) inhibits the phosphorylation of MITA^S366, IRF3^S386 and STAT1^Y701 induced by HSV-1, HSV-2 and HCMV, as well as the phosphorylation of IRF3^S386 and STAT1^Y701 induced by SeV, EMCV and VSV, in THP1 cells.
Sci Bull

Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes. [Abstract]

2024 Dec 30;69(24):3908-3924. PMID: 39550273
Nat Commun

Disrupting sympathetic nerve-tumor crosstalk via biomimetic nanovesicles to augment chemotherapy efficacy under chronic stress. [Abstract]

2026 May 8;17(1):6230. PMID: 42103759
Nat Commun

An artificial cell capable of signal transduction mediated by ADRB2 for the regulation of glycogenolysis. [Abstract]

2026 Jan 16;17(1):1795. PMID: 41545427
Nat Commun

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. [Abstract]

2020 Sep 25;11(1):4857. PMID: 32978402
ACS Nano

Red Blood Cell-Derived Extracellular Vesicles Display Endogenous Antiviral Effects and Enhance the Efficacy of Antiviral Oligonucleotide Therapy. [Abstract]

2023 Nov 14;17(21):21639-21661. PMID: 37852618
J Adv Res

Elevated EBF2 in mouse but not pig drives the progressive brown fat lineage specification via chromatin activation. [Abstract]

2024 Dec 28:S2090-1232(24)00624-6. PMID: 39736442
Redox Biol

Oxidative stress promotes lipid-laden macrophage formation via CYP1B1. [Abstract]

2024 Dec 21:79:103481. PMID: 39721495
Acta Pharm Sin B

2026 Mar 14.
J Exp Clin Cancer Res

Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling. [Abstract]

2019 Apr 25;38(1):174. PMID: 31023336

Isoprenaline purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. [Abstract]

EHD1 stabilizes β2AR. A549 cells are incubated in serum-free 1640 medium for 16 h and then treated with ISO (10 μM) for the indicated times in the presence of cycloheximide (CHX, 20 μg/mL). The cell lysates are analyzed by Western blot.

Isoprenaline purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. [Abstract]

A549 cells were transfected with vector or ShEHD1 and then treated with DMSO or ISO (Isoprenaline) (10 μM; 16 h), and the EHD1 and VEGFA protein levels were assessed by immunoblotting.
Cell Death Differ

Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions. [Abstract]

2023 Mar;30(3):766-778. PMID: 36329235

Isoprenaline purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2023 Mar;30(3):766-778. [Abstract]

SVF differentiated adipocytes were treated with 2 μM isoprenaline (ISO) for 12h followed by Q-PCR analysis of browning genes (n=3). Gene expression is normalized to the 36B4 endogenous control.
Chem Eng J

2024 Sep 1.

Isoprenaline purchased from MedChemExpress. Usage Cited in: Chem Eng J. 2024 Sep 1.

Isoprenaline administration significantly reduces [email protected] anti-inflammatory and antioxidant activities.

Isoprenaline purchased from MedChemExpress. Usage Cited in: Chem Eng J. 2024 Sep 1.

Isoprenaline significantly activates ERK1/2-induced DRP1 phosphorylation on serine 616 (pDRP1).
J Immunother Cancer

ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function. [Abstract]

2025 Jun 12;13(6):e011611. PMID: 40514069
Phytomedicine

Wendan tablet and its active component isocurcumenol protect against myocardial ischemia via targeting ALOX15 and inhibiting lipid peroxidation. [Abstract]

2026 Jun:155:158109. PMID: 41966026
J Pharm Anal

Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor. [Abstract]

2024 Jul;14(7):100934. PMID: 39139999
Acta Pharmacol Sin

The solute carrier transporter SLCO5A1 as a novel therapeutic target for the treatment of myocardial infarction-induced heart failure. [Abstract]

2026 May 27. PMID: 42204299
Acta Pharmacol Sin

YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes. [Abstract]

2025 Jun 11. PMID: 40500343
J Transl Med

Gut microbiota dysbiosis exacerbates heart failure by the LPS-TLR4/NF-κB signalling axis: mechanistic insights and therapeutic potential of TLR4 inhibition. [Abstract]

2025 Jul 10;23(1):762. PMID: 40640887
Biofabrication

Heart-on-a-chip using human iPSC-derived cardiomyocytes with integrated vascular endothelial layer based on culture patch as a potential platform for drug evaluation. [Abstract]

2022 Oct 28;15(1). PMID: 36195063
ACS Appl Mater Interfaces

Insights into the Mechanism of Supramolecular Self-Assembly in the Astragalus membranaceus- Angelica sinensis Codecoction. [Abstract]

2023 Oct 18;15(41):47939-47954. PMID: 37791782
ACS Appl Mater Interfaces

Aligned Nanofibrous Net Deposited Perpendicularly on Microridges Supports Endothelium Formation and Promotes the Structural Maturation of hiPSC-Derived Cardiomyocytes. [Abstract]

2023 Apr 12;15(14):17518-17531. PMID: 36992621
Cell Rep

Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch. [Abstract]

2022 Mar 8;38(10):110468. PMID: 35263588
Cell Rep

Structural Basis of the Diversity of Adrenergic Receptors. [Abstract]

2019 Dec 3;29(10):2929-2935.e4 PMID: 31801060
Chin Med

Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism. [Abstract]

2024 Jun 11;19(1):82. PMID: 38862959
Emerg Microbes Infect

Unique immune and other responses of human nasal epithelial cells infected with H5N1 avian influenza virus compared to seasonal human influenza A and B viruses. [Abstract]

2025 Mar 24:2484330. PMID: 40126073
Ecotoxicol Environ Saf

PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects. [Abstract]

2025 Nov 15:307:119433. PMID: 41273832
Biochem Pharmacol

SD49-7 attenuates cardiac hypertrophy by upregulation of S100B through KDM4A inhibition. [Abstract]

2025 Aug 8;242(Pt 1):117218. PMID: 40784571
Biochem Pharmacol

FGF13 deficiency ameliorates calcium signaling abnormality in heart failure by regulating microtubule stability. [Abstract]

2024 May 29:116329. PMID: 38821375
Life Sci

Oxytocin ameliorates cardiac hypertrophy by inhibiting mitochondrial dysfunction and pyroptosis via AMPK/PGC-1α /TFAM pathway. [Abstract]

2026 Apr 15:391:124281. PMID: 41722768
Life Sci

iNKT cell activation exacerbates isoproterenol-induced cardiac injury through macrophage IFN-γ-STAT1 signaling. [Abstract]

2026 Mar 1:388:124212. PMID: 41539464
Life Sci

Dapagliflozin attenuates post-infarction fibrosis via cardiomyocyte protection and fibroblast inhibition. [Abstract]

2025 Dec 15:383:124083. PMID: 41224193
Food Funct

Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats. [Abstract]

2018 Nov 14;9(11):5528-5535. PMID: 30209468
Nutrients

Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway. [Abstract]

2023 Mar 9;15(6):1340. PMID: 36986070
Can J Cardiol

Canagliflozin Alleviates Pressure Overload-Induced Cardiac Dysfunction via PINK1 Regulation by Inhibiting Mitophagy-Driven Ferroptosis. [Abstract]

2026 Apr 24:S0828-282X(26)00372-7. PMID: 42035950
Eur J Pharmacol

miR-421-mediated suppression of FGF13 as a novel mechanism ameliorates cardiac hypertrophy by inhibiting endoplasmic reticulum stress. [Abstract]

2024 Oct 30:177085. PMID: 39486770
Pharmaceuticals (Basel)

Rhynchosia volubilis Promotes Cell Survival via cAMP-PKA/ERK-CREB Pathway. [Abstract]

2022 Jan 6;15(1):73. PMID: 35056130
Eur J Pharmacol

Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress. [Abstract]

2021 Sep 15:907:174277. PMID: 34171391
Eur J Pharmacol

Tempol prevents isoprenaline-induced takotsubo syndrome via the reactive oxygen species/mitochondrial/anti-apoptosis /p38 MAPK pathway. [Abstract]

2020 Nov 5;886:173439. PMID: 32871175
Int J Mol Sci

ML216 Alleviates Age-Related Cardiac Fibrosis by Suppressing TGF-β1 Signaling Pathway. [Abstract]

2026 Apr 10;27(8):3425. PMID: 42074068
Int Immunopharmacol

Germacrone mitigates cardiac remodeling by regulating PI3K/AKT-mediated oxidative stress, inflammation, and apoptosis. [Abstract]

2023 Sep 5;124(Pt A):110876. PMID: 37683399
Biomolecules

Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway. [Abstract]

2022 Oct 27;12(11):1574. PMID: 36358925
Inflammation

Targeting S100A9 Prevents β-Adrenergic Activation-Induced Cardiac Injury. [Abstract]

2024 Apr;47(2):789-806. PMID: 38446361
mBio

Grass Carp Reovirus Induces Formation of Lipid Droplets as Sites for Its Replication and Assembly. [Abstract]

2022 Dec 20;13(6):e0229722. PMID: 36445081
Molecules

Chlorogenic Acid Attenuates Isoproterenol Hydrochloride-Induced Cardiac Hypertrophy in AC16 Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. [Abstract]

2024 Feb 7;29(4):760. PMID: 38398512
Biochim Biophys Acta Mol Basis Dis

Osteopontin aggravates myocardial fibrosis by promoting phenotypic transition of cardiac fibroblasts via Hippo-YAP pathway. [Abstract]

2025 Dec 31;1872(3):168150. PMID: 41478364
Mol Med Rep

ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway. [Abstract]

2026 Feb;33(2):60. PMID: 41347799
Biochim Biophys Acta Mol Basis Dis

OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes. [Abstract]

2024 Mar;1870(3):167018. PMID: 38185350
Sci Rep

Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts. [Abstract]

2024 Jul 8;14(1):15683. PMID: 38977794
Mol Cell Biochem

Identification of disease-associated gene expression signatures for mechanistic insights and drug prediction in dilated cardiomyopathy-induced heart failure. [Abstract]

2026 Jan 22. PMID: 41569495
J Inflamm Res

Creation of a Rat Takotsubo Syndrome Model and Utilization of Machine Learning Algorithms for Screening Diagnostic Biomarkers. [Abstract]

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Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 10 mg/mL (47.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.7335 mL

23.6675 mL

47.3350 mL

5 mM

0.9467 mL

4.7335 mL

9.4670 mL

10 mM

0.4734 mL

2.3668 mL

4.7335 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-K_m cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7. [Content Brief]

[2]. Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30. [Content Brief]

[3]. Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8. [Content Brief]

[4]. Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700. [Content Brief]

[5]. Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35. [Content Brief]

[6]. M E Conolly, et al. Metabolism of isoprenaline in dog and man. Br J Pharmacol [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.7335 mL	23.6675 mL	47.3350 mL	118.3376 mL
	5 mM	0.9467 mL	4.7335 mL	9.4670 mL	23.6675 mL
	10 mM	0.4734 mL	2.3668 mL	4.7335 mL	11.8338 mL
	15 mM	0.3156 mL	1.5778 mL	3.1557 mL	7.8892 mL
	20 mM	0.2367 mL	1.1834 mL	2.3668 mL	5.9169 mL
	25 mM	0.1893 mL	0.9467 mL	1.8934 mL	4.7335 mL
	30 mM	0.1578 mL	0.7889 mL	1.5778 mL	3.9446 mL
	40 mM	0.1183 mL	0.5917 mL	1.1834 mL	2.9584 mL

Keywords

Isoprenaline

94 Cited Publications

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Isoprenaline

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Publications Citing Use of MedChemExpress (MCE) Isoprenaline

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (94)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Isoprenaline Related Classifications

HY-108353 Related Classifications