Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

  • Bioorg Med Chem Lett. 2005 Jan 17;15(2):251-4. doi: 10.1016/j.bmcl.2004.11.001.
Yutaka Nakajima  1 ,  Hitoshi Hamashima ,  Ken-Ichi Washizuka ,  Yasuyo Tomishima ,  Hiroaki Ohtake ,  Emiko Imamura ,  Toshiko Miura ,  Hiroshi Kayakiri ,  Masayuki Kato
Affiliations
  • 1. Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, Kashima 2-Chome, Yodogawa-Ku, Osaka 532-8514, Japan. [email protected]
PMID: 15603933 DOI: 10.1016/j.bmcl.2004.11.001
Abstract

The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.