1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Adrenergic Receptor
    Endogenous Metabolite
  3. Isoprenaline hemisulfate

Isoprenaline hemisulfate 

Cat. No.: HY-108353A
Handling Instructions

Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.

For research use only. We do not sell to patients.

Isoprenaline hemisulfate Chemical Structure

Isoprenaline hemisulfate Chemical Structure

CAS No. : 299-95-6

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Top Publications Citing Use of Products

    Isoprenaline hemisulfate purchased from MCE. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1373-1385.

    NRCMs are pre-incubated with PCA (50, 100, and 200 μM) for 1 h followed by 10 μM Isoproterenol (ISO) treatment. Cell surface area is measured by rhodamine-phalloidin staining. The expression of β-MHC is detected by Western blot.

    Isoprenaline hemisulfate purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. 

    EHD1 stabilizes β2AR. A549 cells are incubated in serum-free 1640 medium for 16 h and then treated with ISO (10 μM) for the indicated times in the presence of cycloheximide (CHX, 20 μg/mL). The cell lysates are analyzed by Western blot.
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    Description

    Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].

    IC50 & Target

    β adrenergic receptor

     

    In Vitro

    Isoprenaline hemisulfate (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells[1].
    Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity[2].
    Isoprenaline (5 nM and 10 μM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO)[3].
    Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged[4].
    Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current[5].
    Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Isoprenaline hemisulfate (oral, 0.27-0. 64 μg/kg) is extensively metabolizes by a relatively small number of reactions in dogs[6].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Dogs[1]
    Dosage: 0.27-0. 64 μg/kg
    Administration: oral
    Result: Excreted largely unchanged in urine, only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.
    Showed plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.
    . Showed heart rate returned to base-line values when high plasma concentrations.
    Molecular Weight

    260.30

    Formula

    C11H17NO3.1/2H2O4S

    CAS No.
    SMILES

    OC1=CC=C(C(O)CNC(C)C)C=C1O.O=S(O)(O)=O.[0.5]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    Product Name:
    Isoprenaline hemisulfate
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