7683-59-2
7683-59-2
Chemical Structure
Isoprenaline
- CAS No.: 7683-59-2
- Formula:C11H17NO3
- Molecular Weight:211.26
IUPAC Name: 4-(1-hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol
InChIKey: JWZZKOKVBUJMES-UHFFFAOYSA-N
SMILES: OC1=CC=C(C(O)CNC(C)C)C=C1O
Biological Activity: Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isoprenaline | 98.93% | Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma. | ||||||||||||||||||||
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Isoprenaline-d7 acetate | Isoprenalin-d7 acetate is an internal standard for the determination of isoproterenol by GC- or LC-MS. | |||||||||||||||||||||
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Levonordefrin | 98.38% | Levonordefrin ((-)-Cobefrin; (-)-α-Methylnoradrenaline; (-)-Nordefrin) is an α-adrenergic receptor agonist with blood pressure regulatory properties. Levonordefrin is a key metabolite responsible for the hypotensive effect of α-methyldopa. By stimulating central α-adrenergic receptors in the nucleus tractus solitarius region of the medulla oblongata, Levonordefrin induces centrally mediated hypotension and bradycardia. When administered intravenously, Levonordefrin increases mean arterial blood pressure in a dose-dependent manner. Levonordefrin is applicable for research on the pathophysiology of hypertension and drug metabolism. |
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Metaterol | Metaterol is a beta-adrenergic receptor agonist. | |||||||||||||||||||||
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rac-Levonordefrin | Rac-Levonordefrin (rac-Cobefrin; rac-α-Methylnoradrenaline; rac-Nordefrin) is the racemic form of Levonordefrin (HY-107915). Levonordefrin is an α-adrenergic receptor agonist with blood pressure regulating properties. | |||||||||||||||||||||
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Metaproterenol | Metaproterenol (Orciprenaline) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol also has anti-inflammatory activity. | |||||||||||||||||||||
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(-)-Isoproterenol | (-)-Isoproterenol (Levisoprenalinel) is the R-isomer of Isoproterenol. (-)-Isoproterenol can reduce the cleavage of caspase 3 and TNFα levels in retinal endothelial cells (REC). (-)-Isoproterenol can be used for the study of diabetic retinopathy. | |||||||||||||||||||||
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Nordefrin | Nordefrin ((±)-Cobefri), a Norepinephrine (HY-13715) derivative, is a vasoconstrictor agent. | |||||||||||||||||||||
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Deterenol hydrochloride | 99.74% | Deterenol hydrochloride (AL842) is a selective beta-agonist. Deterenol hydrochloride causes vasodepressor, anxiety, increasing heart rate, hypotension palpitation and respiratory distress. | ||||||||||||||||||||
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References
- [1]. Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7. [Content Brief]
- [2]. Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30. [Content Brief]
- [3]. Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8. [Content Brief]
- [4]. Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700. [Content Brief]
- [5]. Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35. [Content Brief]
- [6]. M E Conolly, et al. Metabolism of isoprenaline in dog and man. Br J Pharmacol [Content Brief]
