1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Metaproterenol

Metaproterenol (Synonyms: Orciprenaline)

Cat. No.: HY-B1276A
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Metaproterenol (Orciprenaline) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol also has anti-inflammatory activity.

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Metaproterenol Chemical Structure

Metaproterenol Chemical Structure

CAS No. : 586-06-1

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Description

Metaproterenol (Orciprenaline) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol also has anti-inflammatory activity[1][2].

IC50 & Target

IC50: 68 nM (β2-adrenergic receptor)[1]

In Vitro

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages[1].
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages[1].

Western Blot Analysis[1]

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Enhanced β-arrestin2 and its interaction with IκBα.

RT-PCR[1]

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Led to downregulation of NF-κB.
In Vivo

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications[1].

Molecular Weight

211.26

Formula

C₁₁H₁₇NO₃

CAS No.

586-06-1

SMILES

OC1=CC(C(O)CNC(C)C)=CC(O)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MetaproterenolOrciprenalineAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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