1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Metaproterenol hemisulfate

Metaproterenol hemisulfate (Synonyms: Orciprenaline hemisulfate)

Cat. No.: HY-B1276 Purity: 99.86%
Handling Instructions

Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity.

For research use only. We do not sell to patients.

Metaproterenol hemisulfate Chemical Structure

Metaproterenol hemisulfate Chemical Structure

CAS No. : 5874-97-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 105 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2].

IC50 & Target

IC50: 68 nM (β2-adrenergic receptor)[1]

In Vitro

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages[1].
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages[1].

Western Blot Analysis[1]

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Enhanced β-arrestin2 and its interaction with IκBα.

RT-PCR[1]

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Led to downregulation of NF-κB.
In Vivo

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications[1].

Molecular Weight

260.30

Formula

C₁₁H₁₇NO₃.₁/₂H₂O₄S

CAS No.

5874-97-5

SMILES

O=S(O)(O)=O.OC1=CC(O)=CC(C(O)CNC(C)C)=C1.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (480.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8417 mL 19.2086 mL 38.4172 mL
5 mM 0.7683 mL 3.8417 mL 7.6834 mL
10 mM 0.3842 mL 1.9209 mL 3.8417 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Metaproterenol hemisulfateOrciprenaline hemisulfateAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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Metaproterenol hemisulfate
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