PROTAC AURKA degrader-4
(Pink: Aurora A ligand (HY-168022); Blue: Cereblon ligand (HY-A0003); Black: linker (HY-24057)).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3135155-78-8
- 화학식: C48H48ClN7O8S
- 분자량:918.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
- 순도&문서
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | DC50 |
25.62 nM
|
AURKA protein degradation in human Jurkat acute lymphoblastic leukemia cells assessed via Western blot after 6 h treatment.
AURKA protein degradation in human Jurkat acute lymphoblastic leukemia cells assessed via Western blot after 6 h treatment.
|
42466758 |
| Jurkat | IC50 |
0.81 μM
|
Antiproliferative activity against human Jurkat acute lymphoblastic leukemia cells assessed as reduction in cell viability by CCK8 assay.
Antiproliferative activity against human Jurkat acute lymphoblastic leukemia cells assessed as reduction in cell viability by CCK8 assay.
|
42466758 |
| AGS | IC50 |
30.73 μM
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Antiproliferative activity against human AGS gastric adenocarcinoma cells assessed as reduction in cell viability by CCK8 assay.
Antiproliferative activity against human AGS gastric adenocarcinoma cells assessed as reduction in cell viability by CCK8 assay.
|
42466758 |
| IMR-32 | IC50 |
2.12 μM
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Antiproliferative activity against human IMR-32 neuroblastoma cells assessed as reduction in cell viability by CCK8 assay.
Antiproliferative activity against human IMR-32 neuroblastoma cells assessed as reduction in cell viability by CCK8 assay.
|
42466758 |
| K562 | IC50 |
24.19 μM
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Antiproliferative activity against human K562 chronic myelogenous leukemia cells assessed as reduction in cell viability by CCK8 assay.
Antiproliferative activity against human K562 chronic myelogenous leukemia cells assessed as reduction in cell viability by CCK8 assay.
|
42466758 |
| MOLT-4 | IC50 |
4.46 μM
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Antiproliferative activity against human Molt4 acute lymphoblastic leukemia cells assessed as reduction in cell viability by CCK8 assay.
Antiproliferative activity against human Molt4 acute lymphoblastic leukemia cells assessed as reduction in cell viability by CCK8 assay.
|
42466758 |
| MV4-11 | IC50 |
3.74 μM
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Antiproliferative activity against human MV4-11 acute myeloid leukemia cells assessed as reduction in cell viability by CCK8 assay.
Antiproliferative activity against human MV4-11 acute myeloid leukemia cells assessed as reduction in cell viability by CCK8 assay.
|
42466758 |
| AGS | DC50 |
>1000 nM
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AURKA protein degradation in human AGS gastric adenocarcinoma cells assessed via Western blot after 6 h treatment.
AURKA protein degradation in human AGS gastric adenocarcinoma cells assessed via Western blot after 6 h treatment.
|
42466758 |
| IMR-32 | DC50 |
49.49 nM
|
AURKA protein degradation in human IMR-32 neuroblastoma cells assessed via Western blot after 6 h treatment.
AURKA protein degradation in human IMR-32 neuroblastoma cells assessed via Western blot after 6 h treatment.
|
42466758 |
| K562 | DC50 |
158.47 nM
|
AURKA protein degradation in human K562 chronic myelogenous leukemia cells assessed via Western blot after 6 h treatment.
AURKA protein degradation in human K562 chronic myelogenous leukemia cells assessed via Western blot after 6 h treatment.
|
42466758 |
| MOLT-4 | DC50 |
45.82 nM
|
AURKA protein degradation in human Molt4 acute lymphoblastic leukemia cells assessed via Western blot after 6 h treatment.
AURKA protein degradation in human Molt4 acute lymphoblastic leukemia cells assessed via Western blot after 6 h treatment.
|
42466758 |
| MV4-11 | DC50 |
30.39 nM
|
AURKA protein degradation in human MV4-11 acute myeloid leukemia cells assessed via Western blot after 6 h treatment.
AURKA protein degradation in human MV4-11 acute myeloid leukemia cells assessed via Western blot after 6 h treatment.
|
42466758 |
Chemical Information
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CAS No. 3135155-78-8
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분자량 918.45
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화학식 C48H48ClN7O8S
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SMILES
CC1=C(C=C(C2=C1NC=C2)C3=CC=C(C(OC4=NC=CC=C4)=C3)Cl)C(NS(=O)(N5CCN(CC5)C(CCCCCCCC#CC6=CC=C7C(CN(C7=O)C8CCC(NC8=O)=O)=C6)=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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