1. GPCR/G Protein Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. NTNCB hydrochloride

NTNCB (Compound 11) hydrochloride is a potent and selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a Ki of 8 nM against human Y5.

For research use only. We do not sell to patients.

NTNCB hydrochloride Chemical Structure

NTNCB hydrochloride Chemical Structure

CAS No. : 191931-56-3

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5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1150 In-stock
50 mg USD 1800 In-stock
100 mg USD 2900 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

NTNCB (Compound 11) hydrochloride is a potent and selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a Ki of 8 nM against human Y5[1].

IC50 & Target

hY5 receptor

8 nM (Ki)

hY1 receptor

16032 nM (Ki)

Molecular Weight

508.07

Formula

C25H34ClN3O4S

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=CC=CC=C1[N+]([O-])=O)(NC[C@H]2CC[C@H](CNCC3CC4=C(C=CC=C4)CC3)CC2)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (246.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9682 mL 9.8412 mL 19.6823 mL
5 mM 0.3936 mL 1.9682 mL 3.9365 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9682 mL 9.8412 mL 19.6823 mL 49.2058 mL
5 mM 0.3936 mL 1.9682 mL 3.9365 mL 9.8412 mL
10 mM 0.1968 mL 0.9841 mL 1.9682 mL 4.9206 mL
15 mM 0.1312 mL 0.6561 mL 1.3122 mL 3.2804 mL
20 mM 0.0984 mL 0.4921 mL 0.9841 mL 2.4603 mL
25 mM 0.0787 mL 0.3936 mL 0.7873 mL 1.9682 mL
30 mM 0.0656 mL 0.3280 mL 0.6561 mL 1.6402 mL
40 mM 0.0492 mL 0.2460 mL 0.4921 mL 1.2301 mL
50 mM 0.0394 mL 0.1968 mL 0.3936 mL 0.9841 mL
60 mM 0.0328 mL 0.1640 mL 0.3280 mL 0.8201 mL
80 mM 0.0246 mL 0.1230 mL 0.2460 mL 0.6151 mL
100 mM 0.0197 mL 0.0984 mL 0.1968 mL 0.4921 mL
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NTNCB hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NTNCB hydrochloride
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HY-107733
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