1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. BPR1K871

BPR1K871 (Synonyms: DBPR114)

Cat. No.: HY-100865 Purity: 98.45%
Handling Instructions

BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy.

For research use only. We do not sell to patients.

BPR1K871 Chemical Structure

BPR1K871 Chemical Structure

CAS No. : 2443767-35-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 1134 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy[1].

IC50 & Target

IC50: 19 nM (FLT3), 22 nM (AURKA)[1]

In Vitro

BPR1K871 shows potent anti-proliferative activities in MOLM-13 and MV4-11 AML cells with an EC50 of ~ 5 nM[1].

In Vivo

BPR1K871 is a multi-kinase inhibitor for the treatment of acute myeloid leukemia (AML) and solid tumors[1].

Molecular Weight

526.05

Formula

C₂₅H₂₈ClN₇O₂S

CAS No.

2443767-35-7

SMILES

O=C(NC1=CC(Cl)=CC=C1)NC2=NC=C(S2)CCNC3=NC=NC4=C3C=CC(OCCCN(C)C)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (237.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9010 mL 9.5048 mL 19.0096 mL
5 mM 0.3802 mL 1.9010 mL 3.8019 mL
10 mM 0.1901 mL 0.9505 mL 1.9010 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

BPR1K871DBPR114DBPR 114DBPR-114FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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Product Name:
BPR1K871
Cat. No.:
HY-100865
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