BPR1K871
Based on 1 Customer Validation
BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy.
For research use only. We do not sell to patients.
- Purity: 99.12%
- CAS No.: 2443767-35-7
- Formula: C25H28ClN7O2S
- Molecular Weight:526.05
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Anti-Blood Cancer Compound Library
HY-L079
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Heterocyclic Compound Library
HY-L138
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Membrane Protein-targeted Compound Library
HY-L149
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Highly Selective Inhibitors Library
HY-L158
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Cytokine Inhibitors Library
HY-L161
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
IC50: 19 nM (FLT3), 22 nM (AURKA)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KM12 | IC50 |
>10000 nM
Compound: 10; BPR1K871
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Antiproliferative activity against human KM12 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human KM12 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
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[PMID: 34303872] |
| MOLM-13 | EC50 |
5 nM
Compound: 77
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Cytotoxicity against human MOLM-13 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
Cytotoxicity against human MOLM-13 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
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[PMID: 33243532] |
| MV4-11 | EC50 |
5 nM
Compound: 77
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Cytotoxicity against human MV4-11 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
Cytotoxicity against human MV4-11 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
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[PMID: 33243532] |
BPR1K871 shows potent anti-proliferative activities in MOLM-13 and MV4-11 AML cells with an EC50 of ~ 5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2443767-35-7
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Appearance Solid
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Molecular Weight 526.05
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Formula C25H28ClN7O2S
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Color White to off-white
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SMILES
O=C(NC1=CC(Cl)=CC=C1)NC2=NC=C(S2)CCNC3=NC=NC4=C3C=CC(OCCCN(C)C)=C4
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Synonyms
DBPR114
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (237.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9010 mL | 9.5048 mL | 19.0096 mL | 47.5240 mL |
| 5 mM | 0.3802 mL | 1.9010 mL | 3.8019 mL | 9.5048 mL | |
| 10 mM | 0.1901 mL | 0.9505 mL | 1.9010 mL | 4.7524 mL | |
| 15 mM | 0.1267 mL | 0.6337 mL | 1.2673 mL | 3.1683 mL | |
| 20 mM | 0.0950 mL | 0.4752 mL | 0.9505 mL | 2.3762 mL | |
| 25 mM | 0.0760 mL | 0.3802 mL | 0.7604 mL | 1.9010 mL | |
| 30 mM | 0.0634 mL | 0.3168 mL | 0.6337 mL | 1.5841 mL | |
| 40 mM | 0.0475 mL | 0.2376 mL | 0.4752 mL | 1.1881 mL | |
| 50 mM | 0.0380 mL | 0.1901 mL | 0.3802 mL | 0.9505 mL | |
| 60 mM | 0.0317 mL | 0.1584 mL | 0.3168 mL | 0.7921 mL | |
| 80 mM | 0.0238 mL | 0.1188 mL | 0.2376 mL | 0.5941 mL | |
| 100 mM | 0.0190 mL | 0.0950 mL | 0.1901 mL | 0.4752 mL |
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