1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. BPR1K871

BPR1K871 

Cat. No.: HY-100865
Handling Instructions

BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy.

For research use only. We do not sell to patients.

BPR1K871 Chemical Structure

BPR1K871 Chemical Structure

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Description

BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy[1].

IC50 & Target

IC50: 19 nM (FLT3), 22 nM (AURKA)[1]

In Vitro

BPR1K871 shows potent anti-proliferative activities in MOLM-13 and MV4-11 AML cells with an EC50 of ~ 5 nM[1].

In Vivo

BPR1K871 is a multi-kinase inhibitor for the treatment of acute myeloid leukemia (AML) and solid tumors[1].

Molecular Weight

526.05

Formula

C₂₅H₂₈ClN₇O₂S

SMILES

O=C(NC1=CC(Cl)=CC=C1)NC2=NC=C(S2)CCNC3=NC=NC4=C3C=CC(OCCCN(C)C)=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
BPR1K871
Cat. No.:
HY-100865
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