IK - IK cytokine Gene

Homo sapiens

Also known as RED; RER; CSA2

Gene ID: 3550 | Gene type: protein coding

About IK

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,647,829-140,662,480 (from NCBI)

This gene has 10 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 59.6), bone marrow (RPKM 39.1) and 25 other tissues.

Summary

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]

IK Products(1)

mRNA	Protein	Name
NM_006083.4	NP_006074.2	protein Red

IK Protein Structure

RED_N

RED_C

0
100
200
300
400
500
557 a.a.

Protein Preferred Names

Protein Names

protein Red

IK cytokine, down-regulator of HLA II

Related Diseases

Diseases

Alias

Skin Amelanotic Melanoma

Skin Amelanotic Malignant Melanoma

Amelanotic Skin Melanoma

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Chronic Atrial And Intestinal Dysrhythmia

CAID	Caid Syndrome
Cohesinopathy Affecting Heart And Gut Rhythm	Chronic Atrial Intestinal Dysrhythmia Syndrome
Chronic Atrial And Intestinal Dysrhythmia Syndrome	Chronic Atrial Dysrhythmia-Intestinal Motility Disorder
Dysrhythmia, Atrial And Intestinal, Chronic

Gordon Holmes Syndrome

Cerebellar Ataxia And Hypogonadotropic Hypogonadism	Lhrh Deficiency And Ataxia
Cerebellar Ataxia-Hypogonadism Syndrome	GDHS
Cahh	Luteinizing Hormone-Releasing Hormone Deficiency With Ataxia
Gordon-Holmes Syndrome	Deficiency Of Luteinizing Hormone-Releasing Hormone With Ataxia
Luteinizing Hormone-Releasing Hormone, Deficiency Of, With Ataxia	Cerebellar Ataxia - Hypogonadism
Luteinizing Hormone Releasing Hormone, Deficiency Of With Ataxia	Ataxia, Cerebellar, And Hypogonadotropic Hypogonadism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100795A	Pirmenol hydrochloride	Inhibitor	99.34%	Unkown
HY-100795	Pirmenol		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153585	IK-930	Inhibitor	99.26%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15416	NS309	Activator	99.19%	Unkown
HY-103137	Zacopride hydrochloride		99.69%	Unkown
HY-101253	AM-92016 hydrochloride		≥98.0%	Unkown
HY-112544	IK1 inhibitor PA-6	Inhibitor	99.62%	Unkown
HY-146365	HIV-1 inhibitor-30		/	Unkown
HY-RS06656	IK Human Pre-designed siRNA Set A		/	Unkown
HY-118734	IK-862	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IK	VGNC	VGNC:30100
Felis catus	IK	VGNC	VGNC:67750
Mus musculus	IK	MGD	MGI:1345142
Canis familiaris	IK	VGNC	VGNC:54958
Rattus norvegicus	IK	RGD	RGD:1359352
Macaca mulatta	IK	VGNC	VGNC:73703
Macaca fascicularis	IK	NCBI
Susscrofa domestica	IK	NCBI
Leporidae	IK	NCBI
Others	IK	NCBI

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