1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. AHR antagonist 5 free base

AHR antagonist 5 free base 

Cat. No.: HY-141609
Handling Instructions

AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. AHR antagonist 5 free base effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases.

For research use only. We do not sell to patients.

AHR antagonist 5 free base Chemical Structure

AHR antagonist 5 free base Chemical Structure

CAS No. : 2247950-42-9

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Description

AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. AHR antagonist 5 free base effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases[1].

In Vitro

AHR antagonist 5 free base (Compound A) potently inhibits AHR activity in human and rodent cell lines (IC50 of ~35-150 nM). In human T cell assays, AHR antagonist 5 free base induces an activated T cell state. AHR antagonist 5 free base inhibits CYP1A1 and interleukin (IL)-22 gene expression and leads to an increase in pro-inflammatory cytokines, such as IL-2 and IL-9[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AHR antagonist 5 free base (Compound A) has been evaluated in a series of pharmacological, single-dose and repeated-dose toxicological studies in rodent and non-rodent species including 28-day Good Laboratory Practice (GLP) studies in rat and monkeys. All changes are resolved or resolving after 2 weeks of dosing cessation, except for the testicular changes in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

441.50

Formula

C₂₅H₂₄FN₇

CAS No.
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AHR antagonist 5 free base
Cat. No.:
HY-141609
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