1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. AHR antagonist 5

AHR antagonist 5 

Cat. No.: HY-136220
Handling Instructions

AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.

For research use only. We do not sell to patients.

AHR antagonist 5 Chemical Structure

AHR antagonist 5 Chemical Structure

CAS No. : 2247953-39-3

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Description

AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1[1].

In Vivo

Tumor growth inhibition is statistically significant with AHR antagonist 5 as single. AHR antagonist 5 (10 mg/kg; p.o.; every day for 3 weeks) combination with anti-PD-1 significantly inhibited tumor growth inhibition compared to the anti-PD-1 alone[1].

Animal Model: Balb/c Mice (Mouse Colorectal Cancer Model CT26)[1]
Dosage: 10 mg/kg (combination with anti-PD-1)
Administration: P.o.; every day for 3 weeks
Result: Significantly inhibited tumor growth inhibition.
Molecular Weight

550.89

Formula

C₂₅H₂₇Cl₃FN₇

CAS No.

2247953-39-3

SMILES

CC(C1=C2N(N=C1)C(N[[email protected]]3CC(C4=CC=CC=C4N5)=C5CC3)=NC(C6=CN=CC(F)=C6)=N2)C.Cl.Cl.Cl

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AHR antagonist 5AHR antagonist5AHR antagonist-5Aryl Hydrocarbon ReceptorAhRtumorgrowthcheckpointanti-PD-1B16-IDOcellsC57BL/6miceInhibitorinhibitorinhibit

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AHR antagonist 5
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