2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. AHR antagonist 5 hemimaleate

AHR antagonist 5 hemimaleate, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, has an IC50 of < 0.5 µΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 (WO2018195397, example 39).

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AHR antagonist 5 hemimaleate

AHR antagonist 5 hemimaleate Chemische Struktur

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AHR antagonist 5 hemimaleate Related Antibodies

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Beschreibung

AHR antagonist 5 hemimaleate, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, has an IC50 of < 0.5 µΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 (WO2018195397, example 39)[1].

In Vitro

Tumor growth inhibition is statistically significant with AHR antagonist 5 as single. AHR antagonist 5 (10 mg/kg; p.o.; every day for 3 weeks) combination with anti-PD-1 significantly inhibited tumor growth inhibition compared to the anti-PD-1 alone[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AHR antagonist 5 hemimaleate Related Antibodies
Klinische Studie
Molekulargewicht

499.55

Formel

C27H26O2FN7
SMILES

CC(C1=C2N(N=C1)C(N[C@H]3CC(C4=CC=CC=C4N5)=C5CC3)=NC(C6=CN=CC(F)=C6)=N2)C.O=C(O)/C=C\C(O)=O.[1/2]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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AHR antagonist 5 hemimaleate Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AHR antagonist 5 hemimaleateAryl Hydrocarbon ReceptorAhRtumorgrowthcheckpointanti-PD-1B16-IDOcellsC57BL/6miceInhibitorinhibitorinhibit

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