2. Anti-infection Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis
  3. Parasite Potassium Channel Cytochrome P450 Apoptosis
  4. Quinidine sulfate

Quinidine Monosulfate is an antiarrhythmic agent. Quinidine Monosulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine Monosulfate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine Monosulfate can be used for malaria research.

For research use only. We do not sell to patients.

CAS No. : 50-54-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Quinidine sulfate:

Quinidine sulfate Related Antibodies

Top Publications Citing Use of Products

    Quinidine sulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 19:e05666.  [Abstract]

    Quinidine rescued [Mg2⁺]i levels in LPS‐treated or TRPM7‐silenced DPSCs and SCAP.

    Quinidine sulfate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2021 Aug 15:416:125764.  [Abstract]

    Effects of CYP enzymes inhibitors on metabolic rates of cyproconazole stereoisomers in the in vitro incubation mixtures with RLMs. The asterisks (*) indicates the significant difference in metabolic rates under inhibition compared to the control.

    Quinidine sulfate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Jul 31;11:1038.  [Abstract]

    Cell cycle relative proteins/genes (CyclinD1, CDK4, P21 and P27) level were assessed in HConFs after Quinidine treatment by western blot.

    Quinidine sulfate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2020 Jul 31;11:1038.  [Abstract]

    Cell cycle relative proteins/genes (CyclinD1, CDK4, P21 and P27) level were assessed in HConFs after Atropine/Quinidine treatment by qRT-PCR.

    Quinidine sulfate purchased from MedChemExpress. Usage Cited in: Environ Int. 2019 Jun;127:694-703.  [Abstract]

    CYP2D6 has contributed in the enantioselectivity of IFP and ICPO because the EF value of the KND-supplemented group follows a doseeffect relationship and the difference in the EF values was over 10% relative to the DMSO control group.

    View All Parasite Isoform Specific Products:

    View All Isoforms
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    View All Cytochrome P450 Isoform Specific Products:

    View All Isoforms
    CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Quinidine Monosulfate is an antiarrhythmic agent. Quinidine Monosulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine Monosulfate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine Monosulfate can be used for malaria research[1][2][3][4].

    IC50 & Target

    Plasmodium

     

    In Vitro

    Quinidine Monosulfate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Quinidine sulfate Related Antibodies

    Cell Cytotoxicity Assay[4]

    Cell Line: MES-SA and MESSA/DX5 cells
    Concentration: 10 μM
    Incubation Time: 24 hours
    Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

    Apoptosis Analysis[4]

    Cell Line: MES-SA and MESSA/DX5 cells
    Concentration: 10 μM
    Incubation Time: 24 hours
    Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
    In Vivo

    Quinidine Monosulfate shows effects on the PTZ-induced seizure threshold[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
    Dosage: 10, 20, and 30 mg/kg
    Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
    Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
    Clinical Trial
    Molecular Weight

    373.46

    Formula

    C20H26N2O6S
    CAS No.
    SMILES

    O=S(O)(O)=O.C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.[0.5]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Quinidine sulfate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Quinidine50-54-4ParasitePotassium ChannelCytochrome P450ApoptosisKcsACYPsoral activitymalariaMES-SAMESSA/DX5Inhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Quinidine sulfate
    Cat. No.:
    HY-B1751A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.