1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. IK1 inhibitor PA-6

IK1 inhibitor PA-6 (Synonyms: PA-6)

Cat. No.: HY-112544
Handling Instructions

IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia.

For research use only. We do not sell to patients.

IK1 inhibitor PA-6 Chemical Structure

IK1 inhibitor PA-6 Chemical Structure

CAS No. : 500715-03-7

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Description

IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].

IC50 & Target

IC50: 12-15 nM (KIR2.x currents)[1].

Molecular Weight

492.61

Formula

C₃₁H₃₂N₄O₂

CAS No.

500715-03-7

SMILES

N=C(C1=CC=CC=C1)NC2=CC=C(OCCCCCOC3=CC=C(NC(C4=CC=CC=C4)=N)C=C3)C=C2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IK1 inhibitor PA-6
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HY-112544
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