1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. mAChR
    Potassium Channel
  3. Pirmenol

Pirmenol  (Synonyms: Cl-845 free base; (±)-Pirmenol)

Cat. No.: HY-100795
Handling Instructions

Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation.

For research use only. We do not sell to patients.

Pirmenol Chemical Structure

Pirmenol Chemical Structure

CAS No. : 68252-19-7

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Description

Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation[1][2][4].

IC50 & Target

IC50: 0.1 μM (IK.ACh)[1]

In Vitro

Pirmenol (1 μM) inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells[1].
Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes[3].
Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4].
Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2].
Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Conscious, coronary artery ligated dogs[4]
Dosage: Oral administration (p.o.)
Administration: 2.5 and 5 mg/kg
Result: Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.
Molecular Weight

338.49

Formula

C22H30N2O

CAS No.
SMILES

OC(C1=CC=CC=C1)(CCCN2[[email protected]@H](C)CCC[[email protected]]2C)C3=CC=CC=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pirmenol
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HY-100795
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