2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. mAChR Potassium Channel
  4. Pirmenol

Pirmenol  (Synonyms: (±)-Pirmenol; CI-845 free base)

Cat. No.: HY-100795 Purity: 99.32%
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Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation.

For research use only. We do not sell to patients.

Pirmenol

Pirmenol Chemical Structure

CAS No. : 68252-19-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Pirmenol:

Pirmenol Related Antibodies

Top Publications Citing Use of Products

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation[1][2][4].

IC50 & Target

IC50: 0.1 μM (IK.ACh)[1]
In Vitro

Pirmenol (1 μM) inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells[1].
Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes[3].
Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pirmenol Related Antibodies
In Vivo

Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4].
Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2].
Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Conscious, coronary artery ligated dogs[4]
Dosage: Oral administration (p.o.)
Administration: 2.5 and 5 mg/kg
Result: Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.
Molecular Weight

338.49

Formula

C22H30N2O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(C1=CC=CC=C1)(CCCN2[C@@H](C)CCC[C@H]2C)C3=CC=CC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (24.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9543 mL 14.7715 mL 29.5430 mL
5 mM 0.5909 mL 2.9543 mL 5.9086 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9543 mL 14.7715 mL 29.5430 mL 73.8574 mL
5 mM 0.5909 mL 2.9543 mL 5.9086 mL 14.7715 mL
10 mM 0.2954 mL 1.4771 mL 2.9543 mL 7.3857 mL
15 mM 0.1970 mL 0.9848 mL 1.9695 mL 4.9238 mL
20 mM 0.1477 mL 0.7386 mL 1.4771 mL 3.6929 mL
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Pirmenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pirmenol68252-19-7(±)-PirmenolCI-845CI845CI 845mAChRPotassium ChannelMuscarinic acetylcholine receptorKcsAK+ currentK.Achatrial fibrillationactionpotentialatrialInhibitorinhibitorinhibit

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