HIV-1 inhibitor-30
HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS.
For research use only. We do not sell to patients.
- CAS No.: 2132412-77-0
- Formula: C19H20ClN3O2
- Molecular Weight:357.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
HIV-1 (WT) 40 nM (EC50) |
DNA Polymerase |
RT-K103N 0.72 μM (EC50) |
RT-Y181C 0.04 μM (EC50) |
RT-K103N,Y181C 0.69 μM (EC50) |
RT-L100I,K103N 0.43 μM (EC50) |
RT-Y188L 1.42 μM (EC50) |
RT-K103N,G190A 0.70 μM (EC50) |
RT-K103N,V108I 0.56 μM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HEK-293T | CC50 |
22.06 μM
Compound: 10i
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Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay
Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay
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[PMID: 32004936] |
Chemical Information
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CAS No. 2132412-77-0
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Molecular Weight 357.83
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Formula C19H20ClN3O2
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SMILES
O=C(CC1=CN(C2=C1C=CC=C2)OCCCC)NC3=C(C=NC=C3)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-30 Related Classifications
HY-146365 Related Classifications
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