2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-30

HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS.

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HIV-1 inhibitor-30 Chemical Structure

HIV-1 inhibitor-30 Chemical Structure

CAS No. : 2132412-77-0

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HIV-1 inhibitor-30 Related Antibodies

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Description

HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS[1].

IC50 & Target[1]

HIV-1 (WT)

40 nM (EC50)

RT-K103N

0.72 μM (EC50)

RT-Y181C

0.04 μM (EC50)

RT-K103N,Y181C

0.69 μM (EC50)

RT-L100I,K103N

0.43 μM (EC50)

RT-Y188L

1.42 μM (EC50)

RT-K103N,G190A

0.70 μM (EC50)

RT-K103N,V108I

0.56 μM (EC50)

Molecular Weight

357.83

Formula

C19H20ClN3O2
CAS No.
SMILES

O=C(CC1=CN(C2=C1C=CC=C2)OCCCC)NC3=C(C=NC=C3)Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-302132412-77-0HIVHuman immunodeficiency virusAntiretroviralNNRTI-resistantRT DNA polymeraseAIDSInhibitorinhibitorinhibit

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