HIV-1 inhibitor-30
HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS.
For research use only. We do not sell to patients.
- CAS No.: 2132412-77-0
- Formula: C19H20ClN3O2
- Molecular Weight:357.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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HIV-1 (WT) 40 nM (EC50) |
DNA Polymerase |
RT-K103N 0.72 μM (EC50) |
RT-Y181C 0.04 μM (EC50) |
RT-K103N,Y181C 0.69 μM (EC50) |
RT-L100I,K103N 0.43 μM (EC50) |
RT-Y188L 1.42 μM (EC50) |
RT-K103N,G190A 0.70 μM (EC50) |
RT-K103N,V108I 0.56 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
22.06 μM
Compound: 10i
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Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay
Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay
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[PMID: 32004936] |
Chemical Information
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CAS No. 2132412-77-0
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Molecular Weight 357.83
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Formula C19H20ClN3O2
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SMILES
O=C(CC1=CN(C2=C1C=CC=C2)OCCCC)NC3=C(C=NC=C3)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-30 Related Classifications
HY-146365 Related Classifications
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