2132412-77-0
Chemical Structure
HIV-1 inhibitor-30
- CAS No.: 2132412-77-0
- Formula:C19H20ClN3O2
- Molecular Weight:357.83
IUPAC Name: 6-methyl-N-(3,4,5-trimethoxyphenyl)-1H-indazol-3-amine
InChIKey: JPPDARPGFXISJD-UHFFFAOYSA-N
SMILES: O=C(CC1=CN(C2=C1C=CC=C2)OCCCC)NC3=C(C=NC=C3)Cl
Biological Activity: HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS[1].
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HIV-1 inhibitor-30 | HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS. | |||||||||||||||||||||
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Keywords
