PROTAC Aurora A Degrader-1
PROTAC Aurora A Degrader-1 (Compound 280) is a blood-brain barrier-permeable selective Aurora A PROTAC degrader, with DC50 values of 1 nM and 2 nM in LAN5 and SMS-SAN cells, respectively. PROTAC Aurora A Degrader-1 induces the formation of a ternary complex between AURKA and CRBN, degrades AURKA, reduces MYCN levels, induces DNA damage and apoptosis, exerts antiproliferative activity in cancer cells, and regulates the immune system. PROTAC Aurora A Degrader-1 is applicable to the research of neuroblastoma and small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3115344-59-4
- Formula: C38H43ClN10O3
- Molecular Weight:723.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Aurora A |
Cereblon |
Chemical Information
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CAS No. 3115344-59-4
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Molecular Weight 723.27
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Formula C38H43ClN10O3
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SMILES
CC1=NN(C=C1C2=NC3=C(N2)N=CC(Cl)=C3OC4=CC=C(C=C4)N5CCN(C[C@@H]5C)CC6CCN(CC6)C7=CC=C(C=C7)N8CCC(NC8=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC Aurora A Degrader-1 Related Classifications
HY-181568 Related Classifications
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