PROTAC Aurora A Degrader-1

PROTAC Aurora A Degrader-1 (Compound 280) is a blood-brain barrier-permeable selective Aurora A PROTAC degrader, with DC50 values of 1 nM and 2 nM in LAN5 and SMS-SAN cells, respectively. PROTAC Aurora A Degrader-1 induces the formation of a ternary complex between AURKA and CRBN, degrades AURKA, reduces MYCN levels, induces DNA damage and apoptosis, exerts antiproliferative activity in cancer cells, and regulates the immune system. PROTAC Aurora A Degrader-1 is applicable to the research of neuroblastoma and small cell lung cancer.

For research use only. We do not sell to patients.

  • CAS No.: 3115344-59-4
  • Formula: C38H43ClN10O3
  • Molecular Weight:723.27
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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