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Cat. No.: HY-181568

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PROTAC Aurora A Degrader-1

PROTAC Aurora A Degrader-1 (Compound 280) is a blood-brain barrier-permeable selective Aurora A PROTAC degrader, with DC₅₀ values of 1 nM and 2 nM in LAN5 and SMS-SAN cells, respectively. PROTAC Aurora A Degrader-1 induces the formation of a ternary complex between AURKA and CRBN, degrades AURKA, reduces MYCN levels, induces DNA damage and apoptosis, exerts antiproliferative activity in cancer cells, and regulates the immune system. PROTAC Aurora A Degrader-1 is applicable to the research of neuroblastoma and small cell lung cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3115344-59-4
화학식: C₃₈H₄₃ClN₁₀O₃
분자량:723.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC Aurora A Degrader-1 Chemical Structure

CAS No.: 3115344-59-4

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Aurora A

Cereblon

All PROTACs Isoforms :

All Aurora Kinase Isoforms :

All DNA/RNA Synthesis Isoforms :

Chemical Information

CAS No. 3115344-59-4
분자량 723.27
화학식 C₃₈H₄₃ClN₁₀O₃
SMILES

CC1=NN(C=C1C2=NC3=C(N2)N=CC(Cl)=C3OC4=CC=C(C=C4)N5CCN(C[C@@H]5C)CC6CCN(CC6)C7=CC=C(C=C7)N8CCC(NC8=O)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jeffrey Mihalic, et al. Bifunctional compounds for degrading aurora kinase via ubiquitin proteosome pathway. WO2026020051.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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PROTAC Aurora A Degrader-1

All PROTACs Isoforms

All Aurora Kinase Isoforms

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PROTAC Aurora A Degrader-1 Related Classifications

HY-181568 Related Classifications