1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase

LY3295668 (Synonyms: AK-01)

Cat. No.: HY-114258
Handling Instructions

LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

For research use only. We do not sell to patients.

LY3295668 Chemical Structure

LY3295668 Chemical Structure

CAS No. : 1919888-06-4

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  • Biological Activity

  • Technical Information

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  • References

Description

LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

IC50 & Target[1]

Aurora A

0.8 nM (IC50)

In Vitro

LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0410 mL 10.2051 mL 20.4102 mL
5 mM 0.4082 mL 2.0410 mL 4.0820 mL
10 mM 0.2041 mL 1.0205 mL 2.0410 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

489.95

Formula

C₂₄H₂₆ClF₂N₅O₂

CAS No.

1919888-06-4

SMILES

O=C([[email protected]@]1(CC2=NC(NC3=NNC(C)=C3)=CC=C2F)C[[email protected]@H](C)N(CC4=CC=CC(Cl)=C4F)CC1)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
LY3295668
Cat. No.:
HY-114258
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LY3295668

Cat. No.: HY-114258