1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase

LY3295668 (Synonyms: AK-01)

Cat. No.: HY-114258 Purity: 99.61%
Handling Instructions

LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

For research use only. We do not sell to patients.

LY3295668 Chemical Structure

LY3295668 Chemical Structure

CAS No. : 1919888-06-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

IC50 & Target[1]

Aurora A

0.8 nM (IC50)

In Vitro

LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (306.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0410 mL 10.2051 mL 20.4102 mL
5 mM 0.4082 mL 2.0410 mL 4.0820 mL
10 mM 0.2041 mL 1.0205 mL 2.0410 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

References
Molecular Weight

489.95

Formula

C₂₄H₂₆ClF₂N₅O₂

CAS No.

1919888-06-4

SMILES

O=C([[email protected]@]1(CC2=NC(NC3=NNC(C)=C3)=CC=C2F)C[[email protected]@H](C)N(CC4=CC=CC(Cl)=C4F)CC1)O

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.61%

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Product Name:
LY3295668
Cat. No.:
HY-114258
Quantity:

LY3295668

Cat. No.: HY-114258