PROTAC AURKA degrader 1
PROTAC AURKA degrader 1 is a AURKA PROTAC degrader. PROTAC AURKA degrader 1 forms a ternary complex with AURKA and CRBN E3 ligase, labels AURKA to induce its ubiquitination, and promotes its degradation via the ubiquitin-proteasome system. PROTAC AURKA degrader 1 is applicable to leukemia-related research.
(Pink: Aurora A ligand (HY-175827); Blue: Cereblon ligand (HY-10984); Black: linker (HY-140213)).
For research use only. We do not sell to patients.
- Formula: C48H54ClFN10O10S
- Molecular Weight:1017.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Aurora A |
In Vitro
PROTAC AURKA degrader 1 (Compound A16+X7) (1 µM; 12 h) rapidly and continuously degrades AURKA protein in MV4-11 AURORA-A-Nluc cells, with a maximum degradation rate of 84% and a degradation rate constant of 0.011 min-1[1].
PROTAC AURKA degrader 1 (50 nM-1 μM; 6 h) potently degrades AURKA in MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1017.52
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Formula C48H54ClFN10O10S
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SMILES
O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C(NCCOCCOCCN4C=C(COCCOCCNC(C5(CC6=NC(NC7=NC=CS7)=CC=C6)CCC(OC8=C(F)C(Cl)=CC=C8)CC5)=O)N=N4)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC AURKA degrader 1 Related Classifications
HY-175830 Related Classifications
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