BORA - BORA aurora kinase A activator Gene

Also Known as C13orf34

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79866

About BORA

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:72,727,923-72,756,196 (from NCBI)

This gene has 9 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in lymph node (RPKM 4.2), appendix (RPKM 3.1) and 24 other tissues.

Summary

BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during Mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

BORA Products (4)

mRNA Protein Name
NM_001286746.3 NP_001273675.2 protein aurora borealis isoform 1
NM_001286747.2 NP_001273676.1 protein aurora borealis isoform 3
NM_001366664.2 NP_001353593.1 protein aurora borealis isoform 4
NM_024808.5 NP_079084.4 protein aurora borealis isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16890155 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18521620 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
18521620 GOA
involved in regulation of mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
18521620 GOA
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
18521620 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BORA Protein Structure

BORA_N

BORA_N: Protein aurora borealis N-terminus (1 - 205)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

protein aurora borealis

BORA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BORA Q6PGQ7 AURKA Homo sapiens O14965
Protein Kinase Assay
16890155
Cross: Cross-species interaction Intra: Intraspecies interaction

BORA Antibodies

Cat. No. Product Name Application Reactivity
HY-P82547 Bora Antibody (YA2292) WB, IP Human, Mouse, Rat
HY-P82547A Bora Antibody (YA2292)(PBS only) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Papillary Transitional Carcinoma

  • Papillary Transitional Cell Carcinoma
T2-Low Asthma

  • Type 2 Low Endotype
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D1486 4,4-Difluoro-8-(4'-iodophenyl)-1,7-bis-(1'-napthyl)-4-bora-3alpha,4alpha-diaza-s-indacene / Unkown
HY-RS01577 BORA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W124385 5,5-Difluoro-1,3-dimethyl-5H-5lambda4,6lambda4-dipyrrolo[1,2-c:2',1'-f][1,3 / Unkown
HY-RS21301 Bora Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27820 Bora Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BORA VGNC VGNC:70376
Canis familiaris BORA VGNC VGNC:38499
Rattus norvegicus BORA RGD RGD:1309522
Bos taurus BORA VGNC VGNC:26541
Felis catus BORA VGNC VGNC:60150
Mus musculus BORA MGD MGI:1924994
Others BORA NCBI