1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase
  3. CD532 hydrochloride

CD532 hydrochloride 

Cat. No.: HY-112273A Purity: 99.31%
Handling Instructions

CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.

For research use only. We do not sell to patients.

CD532 hydrochloride Chemical Structure

CD532 hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer[1][2].

In Vivo
Animal Model: Homozygous nu/nu mice with SHH-subtype MYCN-expressing medulloblastoma[1]
Dosage: 25 mg/kg
Administration: I.p. twice weekly for 3 weeks
Result: Decreased the level of MYCN protein and tumor volume and increases survival.
Molecular Weight

558.99

Formula

C₂₆H₂₆ClF₃N₈O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Product Name:
CD532 hydrochloride
Cat. No.:
HY-112273A
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